Anacetrapib

Also known as: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one, MK-0859, Mk-0859, UNII-P7T269PR6S

Anacetrapib (CAS 875446-37-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C30H25F10NO3 and a molecular weight of 637.508 g/mol. Key properties include a boiling point of 555.3±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 289.6±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 875446-37-0
Jingsj CID: J-1955647-9
Molecular Formula: C₃₀H₂₅F₁₀NO₃
Molecular Weight: 637.508 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	555.3±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	289.6±30.1 °C
Exact Mass	637.167480
PSA	38.77000
LogP	8.81
Vapor Pressure	0.0±1.5 mmHg at 25°C
Refractive Index	1.494
Storage Conditions	-20°C

Activity & Biological Data

Target	IC50: 7.9±2.5 nM (rhCETP), 11.8±1.9 nM (CETPC13S)[1]
Additional Information	[1]. Niesor EJ, et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2010, 51(12), 3443-3454. [2]. Dong B, et al. CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism. Atherosclerosis. 2014 Aug;235(2):449-62. [3]. Tan EY, et al. Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys. Drug Metab Dispos. 2010, 38(3), 459-473.

Target

IC50: 7.9±2.5 nM (rhCETP), 11.8±1.9 nM (CETPC13S)[1]

Additional Information

[1]. Niesor EJ, et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2010, 51(12), 3443-3454. [2]. Dong B, et al. CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism. Atherosclerosis. 2014 Aug;235(2):449-62. [3]. Tan EY, et al. Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys. Drug Metab Dispos. 2010, 38(3), 459-473.

Frequently Asked Questions

What is the CAS number of Anacetrapib?

The CAS number of Anacetrapib is 875446-37-0.

What are the molecular formula and molecular weight of Anacetrapib?

Anacetrapib has molecular formula C30H25F10NO3 and molecular weight 637.508 g/mol.

What are the upstream and downstream products of Anacetrapib?

For Anacetrapib, Upstream Products: 4-fluoro-5-isopropyl-2-methoxyphenylboronic acid, 2'-Fluoro-4'-methoxyacetophenone, 1-bromo-4-fluoro-5-isopropyl-2-methoxybenzene.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Anacetrapib (CAS 875446-37-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955647-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.