SNS-314

Also known as: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea, 1-(3-chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea, 1-(3-Chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea, SNS 314, SN-314, AK2, Kinome_3712, UNII-802IFJ0Z8X

SNS-314 (CAS 1057249-41-8) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C18H15ClN6OS2 and a molecular weight of 430.934 g/mol. Key property: a density of 1.6±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1057249-41-8
Jingsj CID: J-1955545-4
Molecular Formula: C₁₈H₁₅ClN₆OS₂
Molecular Weight: 430.934 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.6±0.1 g/cm3
Exact Mass	430.043732
PSA	155.03000
LogP	5.36
Refractive Index	1.815
Storage Conditions	-20℃

Activity & Biological Data

Target	Aurora A:9 nM (IC50) Aurora B:31 nM (IC50) Aurora C:6 nM (IC50)
Additional Information	[1]. Oslob JD, et al. Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4. [2]. Arbitrario JP, et al. SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17.

Frequently Asked Questions

What is the CAS number of SNS-314?

The CAS number of SNS-314 is 1057249-41-8.

What are the molecular formula and molecular weight of SNS-314?

SNS-314 has molecular formula C18H15ClN6OS2 and molecular weight 430.934 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "SNS-314 (CAS 1057249-41-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955545-4 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.