Triapine
Also known as: 3-AP, PAN-811, NSC 663249, (2E)-2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide, 2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide, 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone, Hydrazinecarbothioamide, 2-[(3-amino-2-pyridinyl)methylene]-
Triapine (CAS 143621-35-6) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C7H9N5S and a molecular weight of 195.245 g/mol. Key properties include a melting point of 234°C(lit.), a boiling point of 436.0±55.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 217.5±31.5 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 143621-35-6
- Jingsj CID
- J-1955499-5
- Molecular Formula
- C7H9N5S
- Molecular Weight
- 195.245 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 234°C(lit.) |
|---|---|
| Boiling Point | 436.0±55.0 °C at 760 mmHg |
| Density | 1.5±0.1 g/cm3 |
| Flash Point | 217.5±31.5 °C |
| Exact Mass | 195.057861 |
| PSA | 125.95000 |
| LogP | 0.98 |
| Appearance | white to light brown |
| Vapor Pressure | 0.0±1.0 mmHg at 25°C |
| Refractive Index | 1.720 |
| Storage Conditions | 2-8°C |
| Additional Property | DMSO: soluble10Meq/mL, clear |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | Ribonucleotide reductase (RR)[1] |
|---|---|
| Additional Information | [1]. Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e475-81. [2]. Yalowich JC, et al. The anticancer thiosemicarbazones Dp44mT and Triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα. Biochem Pharmacol. 2012 Jul 1;84(1):52-8. [3]. Whitnall M, et al. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6. |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Triapine?
The CAS number of Triapine is 143621-35-6.
What are the molecular formula and molecular weight of Triapine?
Triapine has molecular formula C7H9N5S and molecular weight 195.245 g/mol.
Is Triapine hazardous?
Triapine has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.
What are the upstream and downstream products of Triapine?
For Triapine, Upstream Products: 2-Methyl-3-nitropyridine, 3-Nitropyridine-2-carbaldehyde, Thiosemicarbazide.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Triapine (CAS 143621-35-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955499-5 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.