Rigosertib

Also known as: (2-Methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethenesulfonylmethyl]phenylamino)acetic acid, N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine, ON-01910, CS-1407, (E)-2,4,6-Trimethoxystyryl 3-[(carboxymethyl)amino]-4-methoxybenzyl sulfone, Glycine, N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-, Rigosertib (acid), UNII-67DOW7F9GL

Rigosertib (CAS 592542-59-1) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H25NO8S and a molecular weight of 451.49000 g/mol. Key properties include a melting point of 172-174 ºC (acetone ) and a density of 1.332±0.06 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 592542-59-1
Jingsj CID: J-1955497-3
Molecular Formula: C₂₁H₂₅NO₈S
Molecular Weight: 451.49000 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	172-174 ºC (acetone )
Density	1.332±0.06 g/cm3
Exact Mass	451.13000
PSA	128.77000
LogP	3.95700
Storage Conditions	2-8℃
Additional Property	Practically insoluble (0.011 g/L) (25 ºC)

Activity & Biological Data

Target	PLK1:9 nM (IC50) PLK2:260 nM (IC50) PDGFR:18 nM (IC50) Src:155 nM (IC50) BCR-ABL:32 nM (IC50) Cdk1:260 nM (IC50) Flt1:42 nM (IC50) Fyn:182 nM (IC50)
Additional Information	[1]. Gumireddy K, et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005 Mar;7(3):275-86. [2]. Reddy MV, et al. Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity. J Med Chem. [3]. Chapman CM, et al. ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91.

Target

PLK1:9 nM (IC50) PLK2:260 nM (IC50) PDGFR:18 nM (IC50) Src:155 nM (IC50) BCR-ABL:32 nM (IC50) Cdk1:260 nM (IC50) Flt1:42 nM (IC50) Fyn:182 nM (IC50)

Additional Information

[1]. Gumireddy K, et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005 Mar;7(3):275-86. [2]. Reddy MV, et al. Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity. J Med Chem. [3]. Chapman CM, et al. ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91.

Frequently Asked Questions

What is the CAS number of Rigosertib?

The CAS number of Rigosertib is 592542-59-1.

What are the molecular formula and molecular weight of Rigosertib?

Rigosertib has molecular formula C21H25NO8S and molecular weight 451.49000 g/mol.

What are the upstream and downstream products of Rigosertib?

For Rigosertib, Upstream Products: 4-Methoxy-3-nitrobenzyl bromide, 2-[[(4-methoxy-3-nitrophenyl)methyl]thio]acetic acid, 4-Methoxy-3-nitrobenzylsulfonylacetic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Rigosertib (CAS 592542-59-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955497-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.