Toceranib

Also known as: SU11654, SU-11654, PHA 291639, PHA-291639, PHA291639, (Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrrole-3-carboxamide, 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide

Toceranib (CAS 356068-94-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H25FN4O2 and a molecular weight of 396.45800 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 356068-94-5
Jingsj CID: J-1955477-9
Molecular Formula: C₂₂H₂₅FN₄O₂
Molecular Weight: 396.45800 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	396.19600
PSA	84.21000
LogP	3.68670
Storage Conditions	-20C

Activity & Biological Data

Target	PDGFRβ:5 nM (Ki) Flk-1:6 nM (Ki)
Additional Information	[1]. London CA, et al. Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies. Clin Cancer Res. 2003 Jul;9(7):2755-68. [2]. Halsey CH, et al. Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia?) in canine mast cell tumor. BMC Vet Res. 2014 May 6;10:105. [3]. Mitchell L, et al. Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer. J Vet Intern Med. 2012 Mar-Apr;26(2):355-62.

Target

PDGFRβ:5 nM (Ki) Flk-1:6 nM (Ki)

Additional Information

[1]. London CA, et al. Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies. Clin Cancer Res. 2003 Jul;9(7):2755-68. [2]. Halsey CH, et al. Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia?) in canine mast cell tumor. BMC Vet Res. 2014 May 6;10:105. [3]. Mitchell L, et al. Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer. J Vet Intern Med. 2012 Mar-Apr;26(2):355-62.

Frequently Asked Questions

What is the CAS number of Toceranib?

The CAS number of Toceranib is 356068-94-5.

What are the molecular formula and molecular weight of Toceranib?

Toceranib has molecular formula C22H25FN4O2 and molecular weight 396.45800 g/mol.

What are the upstream and downstream products of Toceranib?

For Toceranib, Upstream Products: 1-(2-Aminoethyl)pyrrolidine, (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid, 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Toceranib (CAS 356068-94-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955477-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.