Ilomastat

Also known as: GM6001, Galardin, GM 6001, Galardin CS 610, CS-1405, GM-6001, Ilomastat (GM6001, Galardin), (2R)-N-Hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxo-2-propanyl]-2-isobutylsuccinamide, (2R)-N-Hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-isobutylsuccinamide, (2R)-N4-(hydroxy)-N1-((1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl)-2-(2-methylpropyl)butanediamide, (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-butanediamide, Butanediamide, N-hydroxy-N-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-, (S-(R*,S*))-N4-Hydroxy-N{1}-(1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl)-2-(2-methylpropyl)butanediamide, (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide, (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide

Ilomastat (CAS 142880-36-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H28N4O4 and a molecular weight of 388.461 g/mol. Key property: a density of 1.228±0.06 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 142880-36-2
Jingsj CID: J-1955401-9
Molecular Formula: C₂₀H₂₈N₄O₄
Molecular Weight: 388.461 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.228±0.06 g/cm3
Exact Mass	388.211060
PSA	123.32000
LogP	0.83
Appearance	Off-white solid
Refractive Index	1.590
Storage Conditions	2-8°C
Additional Property	Practically insoluble (0.062 g/L) (25 ºC)

Activity & Biological Data

Target	Ki: 0.4 nM (MMP-1), 0.5 nM (MMP-2), 27 nM (MMP-3), 3.7 nM (MMP-7), 0.1 nM (MMP-8), 0.2 nM (MMP-9), 3.6 nM (MMP-12), 13.4 nM (MMP-14), 0.36 nM (MMP-26)
Additional Information	[1]. Grobelny D, et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry. 1992 Aug 11;31(31):7152-4. [2]. Schultz GS, et al. Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest Ophthalmol Vis Sci. 1992 Nov;33(12):3325-31. [3]. Li C, et al. Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor. J Am Coll Cardiol. 2002 Jun 5;39(11):1852-8. [4]. Leppert D, et al. T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol. 1995 May 1;154(9):4379-89.

Target

Ki: 0.4 nM (MMP-1), 0.5 nM (MMP-2), 27 nM (MMP-3), 3.7 nM (MMP-7), 0.1 nM (MMP-8), 0.2 nM (MMP-9), 3.6 nM (MMP-12), 13.4 nM (MMP-14), 0.36 nM (MMP-26)

Additional Information

[1]. Grobelny D, et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry. 1992 Aug 11;31(31):7152-4. [2]. Schultz GS, et al. Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest Ophthalmol Vis Sci. 1992 Nov;33(12):3325-31. [3]. Li C, et al. Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor. J Am Coll Cardiol. 2002 Jun 5;39(11):1852-8. [4]. Leppert D, et al. T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol. 1995 May 1;154(9):4379-89.

Frequently Asked Questions

What is the CAS number of Ilomastat?

The CAS number of Ilomastat is 142880-36-2.

What are the molecular formula and molecular weight of Ilomastat?

Ilomastat has molecular formula C20H28N4O4 and molecular weight 388.461 g/mol.

What are the upstream and downstream products of Ilomastat?

For Ilomastat, Upstream Products: (2-Methyl-2-propenyl)succinic Anhydride, N-[(tert-Butoxy)carbonyl]-L-tryptophan.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ilomastat (CAS 142880-36-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955401-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.