R547

Also known as: (4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone, (4-Amino-2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-5-pyrimidinyl)(2,3-difluoro-6-methoxyphenyl)methanone, (4-Amino-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone, 3-difluoro-6-Methoxyphenyl)-, 5-[(2,3-difluoro-6-Methoxyphenyl)carbonyl]-2-N-(1-Methanesulfonylpiperidin-4-yl)pyriMidine-2,4-diaMine, Methanone, [4-amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)-, R 547, R547(Ro 4584820), RO-4584820, Ro 4584820, [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone, [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547), [4-aMino-2-[[1-(Methylsulfonyl)-4-piperidinyl]aMino]-5-pyriMidinyl](2, [4-amino-2-(1-methanesulfonyl-piperidin-4-ylamino)-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanone, [4-amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl]-(2,3-difluoro-6-methoxyphenyl)methanone, cc-270, pound not R 547

R547 (CAS 741713-40-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C18H21F2N5O4S and a molecular weight of 441.45200 g/mol. Key properties include a boiling point of 703.7ºC at 760 mmHg, a density of 1.49 and a flash point of 379.4ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 741713-40-6
Jingsj CID: J-1955108-7
Molecular Formula: C₁₈H₂₁F₂N₅O₄S
Molecular Weight: 441.45200 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	703.7ºC at 760 mmHg
Density	1.49
Flash Point	379.4ºC
Exact Mass	441.12800
PSA	135.89000
LogP	3.08540
Refractive Index	1.62
Storage Conditions	-20℃

Activity & Biological Data

Target	Cdk1/cyclin B:2 nM (Ki) CDK4/cyclin D:1 nM (Ki) CDK2/cyclinE:3 nM (Ki)
Additional Information	[1]. Chu XJ, DePinto W, Bartkovitz D, So SS, Vu BT, Packman K, Lukacs C, Ding Q, Jiang N, Wang K, Goelzer P, Yin X, Smith MA, Higgins BX, Chen Y, Xiang Q, Moliterni J, Kaplan G, Graves B, Lovey A, Fotouhi N.Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4 [2]. Bayés M, Rabasseda X, Prous JR.Gateways to clinical trials.Methods Find Exp Clin Pharmacol. 2007 Jul-Aug;29(6):427-37. [3]. Martin F, Thomson TM, Sewer A, Drubin DA, Mathis C, Weisensee D, Pratt D, Hoeng J, Peitsch MC.Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks.BMC Syst Biol. 2012 May 31;6:54. [4]. DePinto, Wanda et al In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials Molecular Cancer Therapeutics (2006), 5(11), 2644-2658 [5]. Jones, Clifford D.; Andrews, David M. Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors Bioorganic & Medicinal Chemistry Letters (2008), 18(24), 6486-6489

Target

Cdk1/cyclin B:2 nM (Ki) CDK4/cyclin D:1 nM (Ki) CDK2/cyclinE:3 nM (Ki)

Additional Information

[1]. Chu XJ, DePinto W, Bartkovitz D, So SS, Vu BT, Packman K, Lukacs C, Ding Q, Jiang N, Wang K, Goelzer P, Yin X, Smith MA, Higgins BX, Chen Y, Xiang Q, Moliterni J, Kaplan G, Graves B, Lovey A, Fotouhi N.Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4 [2]. Bayés M, Rabasseda X, Prous JR.Gateways to clinical trials.Methods Find Exp Clin Pharmacol. 2007 Jul-Aug;29(6):427-37. [3]. Martin F, Thomson TM, Sewer A, Drubin DA, Mathis C, Weisensee D, Pratt D, Hoeng J, Peitsch MC.Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks.BMC Syst Biol. 2012 May 31;6:54. [4]. DePinto, Wanda et al In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials Molecular Cancer Therapeutics (2006), 5(11), 2644-2658 [5]. Jones, Clifford D.; Andrews, David M. Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors Bioorganic & Medicinal Chemistry Letters (2008), 18(24), 6486-6489

Frequently Asked Questions

What is the CAS number of R547?

The CAS number of R547 is 741713-40-6.

What are the molecular formula and molecular weight of R547?

R547 has molecular formula C18H21F2N5O4S and molecular weight 441.45200 g/mol.

What are the upstream and downstream products of R547?

For R547, Upstream Products: 4-Amino-1-(methylsulfonyl)piperidine, (4-Amino-2-(ethylthio)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone, 4-Amino-2-(ethylthio)-N-methoxy-N-methylpyrimidine-5-carboxamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "R547 (CAS 741713-40-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955108-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.