Enzastaurin
Also known as: LY317615, LY 317615, LY-317615, 3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(2-pyridinylmethyl)-4-piperidinyl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione, 3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Enzastaurin (CAS 170364-57-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C32H29N5O2 and a molecular weight of 515.605 g/mol. Key properties include a melting point of 249-261℃, a boiling point of 767.2±60.0 °C at 760 mmHg, a density of 1.34 and a flash point of 417.8±32.9 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H413. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 170364-57-5
- Jingsj CID
- J-1955071-1
- Molecular Formula
- C32H29N5O2
- Molecular Weight
- 515.605 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 249-261℃ |
|---|---|
| Boiling Point | 767.2±60.0 °C at 760 mmHg |
| Density | 1.34 |
| Flash Point | 417.8±32.9 °C |
| Exact Mass | 515.232117 |
| PSA | 72.16000 |
| LogP | 4.43 |
| Appearance | powder,light orange to dark orange-red |
| Vapor Pressure | 0.0±2.6 mmHg at 25°C |
| Refractive Index | 1.723 |
| Storage Conditions | -20°C |
| Additional Property | DMSO: soluble10mg/mL, clear (warmed) |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H413
Activity & Biological Data
| Target | PKCβ:6 nM (IC50) PKCα:39 nM (IC50) PKCγ:83 nM (IC50) PKCε:110 nM (IC50) |
|---|---|
| Additional Information | [1]. Rovedo MA, et al. Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin. J Invest Dermatol, 2011, 131(7), 1442-1449. [2]. Podar K, et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). Blood, 2007, 109(4), 1669-1677. [3]. Graff JR, et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res, 2005, 65(16), |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Enzastaurin?
The CAS number of Enzastaurin is 170364-57-5.
What are the molecular formula and molecular weight of Enzastaurin?
Enzastaurin has molecular formula C32H29N5O2 and molecular weight 515.605 g/mol.
Is Enzastaurin hazardous?
Enzastaurin has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H413.
What are the upstream and downstream products of Enzastaurin?
For Enzastaurin, Upstream Products: Methyl (1-methylindolyl)-3-glyoxylate, 2-(1-Methyl-1H-indol-3-yl)acetamide, 2-(Bromomethyl)pyridine hydrobromide.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Enzastaurin (CAS 170364-57-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955071-1 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.