Pioglitazone

Also known as: Actos, U 72107, 5-[4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzyl]thiazolidine-2,4-dione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, 5-{4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione, (±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

Pioglitazone (CAS 111025-46-8) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C19H20N2O3S and a molecular weight of 356.44 g/mol. Key properties include a melting point of 183-184ºC, a boiling point of 575.4±45.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 301.8±28.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 111025-46-8
Jingsj CID: J-19545-4
Molecular Formula: C₁₉H₂₀N₂O₃S
Molecular Weight: 356.44 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	183-184ºC
Boiling Point	575.4±45.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	301.8±28.7 °C
PSA	93.59000
LogP	2.94
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.611

Activity & Biological Data

Target	PPARδ:0.01 μM (EC50, Human PPARδ) PPARα:0.93 μM (EC50, Human PPARα) PPARγ:43 μM (EC50, Human PPARγ)
Additional Information	[1]. Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve [2]. Puddu A, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84. [3]. Kubota N, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281(13):8748-55. [4]. Elrashidy RA, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):324-33.

Target

PPARδ:0.01 μM (EC50, Human PPARδ) PPARα:0.93 μM (EC50, Human PPARα) PPARγ:43 μM (EC50, Human PPARγ)

Additional Information

[1]. Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve [2]. Puddu A, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84. [3]. Kubota N, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281(13):8748-55. [4]. Elrashidy RA, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):324-33.

Frequently Asked Questions

What is the CAS number of Pioglitazone?

The CAS number of Pioglitazone is 111025-46-8.

What are the molecular formula and molecular weight of Pioglitazone?

Pioglitazone has molecular formula C19H20N2O3S and molecular weight 356.44 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Pioglitazone (CAS 111025-46-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-19545-4 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.