Raltitrexed

Also known as: Tomudex, ZD-1694, ICI-D-1694, N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic acid, (2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid, N-[(5-{Methyl[(2-methyl-4-oxo-1,4-dihydro-6-quinazolinyl)methyl]amino}-2-thienyl)carbonyl]-L-glutamic acid, D1694, ICI D1694

Raltitrexed (CAS 112887-68-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H22N4O6S and a molecular weight of 458.488 g/mol. Key properties include a melting point of 176-1800C and a density of 1.5±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 112887-68-0
Jingsj CID: J-19537-9
Molecular Formula: C₂₁H₂₂N₄O₆S
Molecular Weight: 458.488 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	176-1800C
Density	1.5±0.1 g/cm3
Exact Mass	458.126007
PSA	180.93000
LogP	-1.28
Refractive Index	1.692
Storage Conditions	Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Activity & Biological Data

Additional Information	[1]. Zhao H, et al. Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. Oncol Res. 2016;23(5):237-48 [2]. Dong Y, et al. Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation. Mol Cell Biochem. 2015 Jan;398(1-2):223-31. [3]. Xue S, et al. Raltitrexed induces mitochondrial-mediated apoptosis in SGC7901 human gastric cancer cells. Mol Med Rep. 2014 Oct;10(4):1927-34. [4]. Waldman BC, et al. Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. DNA Repair (Amst). 2008 Oct 1;7(10):1624-35.

Additional Information

[1]. Zhao H, et al. Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. Oncol Res. 2016;23(5):237-48 [2]. Dong Y, et al. Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation. Mol Cell Biochem. 2015 Jan;398(1-2):223-31. [3]. Xue S, et al. Raltitrexed induces mitochondrial-mediated apoptosis in SGC7901 human gastric cancer cells. Mol Med Rep. 2014 Oct;10(4):1927-34. [4]. Waldman BC, et al. Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. DNA Repair (Amst). 2008 Oct 1;7(10):1624-35.

Frequently Asked Questions

What is the CAS number of Raltitrexed?

The CAS number of Raltitrexed is 112887-68-0.

What are the molecular formula and molecular weight of Raltitrexed?

Raltitrexed has molecular formula C21H22N4O6S and molecular weight 458.488 g/mol.

What are the upstream and downstream products of Raltitrexed?

For Raltitrexed, Upstream Products: Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate, 6-(Bromomethyl)-2-methyl-4(3H)-quinazolinone, Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Raltitrexed (CAS 112887-68-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-19537-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.