Vorinostat

Also known as: SAHA, Suberoylanilide hydroxamic acid, Zolinza, N-Hydroxy-N'-phenyloctanediamide, Octanediamide, N1-hydroxy-N8-phenyl-, Suberanilohydroxamic acid, Vorinostat (SAHA)

Vorinostat (CAS 149647-78-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C14H20N2O3 and a molecular weight of 264.320 g/mol. Key properties include a melting point of 161-162°C and a density of 1.2±0.1 g/cm3. It is classified under GHS with signal word Danger and hazard statements H341 — Suspected of causing genetic defects and H360 — May damage fertility or the unborn child. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 149647-78-9
Jingsj CID: J-18888-5
Molecular Formula: C₁₄H₂₀N₂O₃
Molecular Weight: 264.320 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	161-162°C
Density	1.2±0.1 g/cm3
Exact Mass	264.147400
PSA	78.43000
LogP	0.86
Refractive Index	1.567
Storage Conditions	-20°C Freezer

GHS Safety & Compliance

Health HazardSignal word: Danger

H341 — Suspected of causing genetic defects
H360 — May damage fertility or the unborn child

Activity & Biological Data

Target	HDAC1:10 nM (ID50) HDAC3:20 nM (ID50) HDAC2 HDAC7 HDAC11 Mitophagy Autophagy
Additional Information	[1]. Hrzenjak A et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer. 2010 Mar 4;9:49. [2]. Lautz TB, et al. The effect of vorinostat on the development of resistance to Doxorubicin in neuroblastoma.PLoS One. 2012;7(7):e40816. [3]. Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7. [4]. Xu WS, et al. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene. 2007 Aug 13;26(37):5541-52. [5]. Pérez-Cañamás A, et al. Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease. Mol Psychiatry. 2017 May;22(5):711-723. [6]. Wang J, et al. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1. Nat Commun. 2017 Dec 20;8(1):2207.

Target

HDAC1:10 nM (ID50) HDAC3:20 nM (ID50) HDAC2 HDAC7 HDAC11 Mitophagy Autophagy

Additional Information

[1]. Hrzenjak A et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer. 2010 Mar 4;9:49. [2]. Lautz TB, et al. The effect of vorinostat on the development of resistance to Doxorubicin in neuroblastoma.PLoS One. 2012;7(7):e40816. [3]. Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7. [4]. Xu WS, et al. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene. 2007 Aug 13;26(37):5541-52. [5]. Pérez-Cañamás A, et al. Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease. Mol Psychiatry. 2017 May;22(5):711-723. [6]. Wang J, et al. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1. Nat Commun. 2017 Dec 20;8(1):2207.

Customs & Trade Information

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Vorinostat?

The CAS number of Vorinostat is 149647-78-9.

What are the molecular formula and molecular weight of Vorinostat?

Vorinostat has molecular formula C14H20N2O3 and molecular weight 264.320 g/mol.

Is Vorinostat hazardous?

Vorinostat has GHS signal word Danger and hazard statements H341 — Suspected of causing genetic defects; H360 — May damage fertility or the unborn child.

What are the upstream and downstream products of Vorinostat?

For Vorinostat, Upstream Products: 7-Phenylcarbamoylheptanoic acid, Methyl 8-oxo-8-(phenylamino)octanoate, Suberic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Vorinostat (CAS 149647-78-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-18888-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.