Sirolimus

Also known as: Rapamycin, AY 22989, AY-22989, RAPAMUNE, RPM, Rapamicin, 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine

Sirolimus (CAS 53123-88-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C51H79NO13 and a molecular weight of 914.172 g/mol. Key properties include a melting point of 183-185°C, a boiling point of 973.0±75.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 542.3±37.1 °C. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H302 — Harmful if swallowed and H312 — Harmful in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 53123-88-9
Jingsj CID: J-18598-8
Molecular Formula: C₅₁H₇₉NO₁₃
Molecular Weight: 914.172 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	183-185°C
Boiling Point	973.0±75.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	542.3±37.1 °C
Exact Mass	913.555115
PSA	195.43000
LogP	3.54
Vapor Pressure	0.0±0.6 mmHg at 25°C
Refractive Index	1.551

GHS Safety & Compliance

Flammable / IrritantSignal word: Danger

H225 — Highly flammable liquid and vapour
H302 — Harmful if swallowed
H312 — Harmful in contact with skin
H332 — Harmful if inhaled
H319 — Causes serious eye irritation

Activity & Biological Data

Target	mTOR:0.1 nM (IC50) Autophagy
Additional Information	[1]. Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282(18), 13395-13401. [2]. Lalic H, et al. Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells. Leuk Lymphoma. 2012 Nov;53(11):2253-61. [3]. Takeuchi H, et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res, 2005, 65(8), 3336-3346. [4]. Bodine SC, et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol, 2001, 3(11), 1014-1019. [5]. Marin TM, et al. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associatedPTPN11 mutation. J Clin Invest. 2011 Mar;121(3):1026-43.

Target

mTOR:0.1 nM (IC50) Autophagy

Additional Information

[1]. Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282(18), 13395-13401. [2]. Lalic H, et al. Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells. Leuk Lymphoma. 2012 Nov;53(11):2253-61. [3]. Takeuchi H, et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res, 2005, 65(8), 3336-3346. [4]. Bodine SC, et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol, 2001, 3(11), 1014-1019. [5]. Marin TM, et al. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associatedPTPN11 mutation. J Clin Invest. 2011 Mar;121(3):1026-43.

Customs & Trade Information

HS Code	2942000000

Frequently Asked Questions

What is the CAS number of Sirolimus?

The CAS number of Sirolimus is 53123-88-9.

What are the molecular formula and molecular weight of Sirolimus?

Sirolimus has molecular formula C51H79NO13 and molecular weight 914.172 g/mol.

Is Sirolimus hazardous?

Sirolimus has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H302 — Harmful if swallowed; H312 — Harmful in contact with skin.

What are the upstream and downstream products of Sirolimus?

For Sirolimus, Upstream Products: Dimethylphosphinic chloride; Downstream Products: Ridaforolimus, L-Pipecolic acid, Dimethylphosphinic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Sirolimus (CAS 53123-88-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-18598-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.