Alpelisib (BYL719)
Also known as: (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide, (2S)-N-{4-Methyl-5-[2-(1,1,1-trifluoro-2-methyl-2-propanyl)-4-pyridinyl]-1,3-thiazol-2-yl}-1,2-pyrrolidinedicarboxamide, (2S)-N1 -{4-methyl-5-[1-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin- 4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide, (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide, (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}amide, 1,2-Pyrrolidinedicarboxamide, N-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-, ALPELISIB, Alpelisib, BLV-719, BYL 719, BYL-719, BYL-719 /BYL719, BYL719, CS-614, QCR-1, UNII:08W5N2C97Q
Alpelisib (BYL719) (CAS 1217486-61-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C19H22F3N5O2S and a molecular weight of 441.470 g/mol. Key property: a density of 1.4±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 1217486-61-7
- Jingsj CID
- J-1859-7
- Molecular Formula
- C19H22F3N5O2S
- Molecular Weight
- 441.470 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Exact Mass | 441.144623 |
| PSA | 133.93000 |
| LogP | -0.02 |
| Refractive Index | 1.587 |
| Storage Conditions | -20℃ |
Activity & Biological Data
| Target | p110α:5 nM (IC50) p110γ:250 nM (IC50) p110δ:290 nM (IC50) p110β:1200 nM (IC50) |
|---|---|
| Additional Information | [1]. Furet P, et al. Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3741-8. [2]. Fritsch C, et al. Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials. Mol Cancer Ther. 2014 May;13(5):1117-29. [3]. Gobin B, et al. BYL719, a new α-specific PI3K inhibitor: single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma. Int J Cancer. 2015 Feb 15;136(4):784-96. [4]. Venot Q, et al. Targeted therapy in patients with PIK3CA-related overgrowth syndrome. Nature. 2018 Jun;558(7711):540-546. [5]. Ding J, et al. Inhibition of BTF3 sensitizes luminal breast cancer cells to PI3Kα inhibition through the transcriptional regulation of ERα. Cancer Lett. 2018 Oct 10;440-441:54-63. |
Frequently Asked Questions
What is the CAS number of Alpelisib (BYL719)?
The CAS number of Alpelisib (BYL719) is 1217486-61-7.
What are the molecular formula and molecular weight of Alpelisib (BYL719)?
Alpelisib (BYL719) has molecular formula C19H22F3N5O2S and molecular weight 441.470 g/mol.
What are the upstream and downstream products of Alpelisib (BYL719)?
For Alpelisib (BYL719), Upstream Products: L-Prolinamide, 2,4-Lutidine, 1-(4-methylpyridin-2-yl)ethanone.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Alpelisib (BYL719) (CAS 1217486-61-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1859-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.