2-Chloro-6-(trifluoromethyl)nicotinic acid

Also known as: 2-Chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid, 2-Chloro-6-trifluoromethylnicotinic acid, 2-Chloro-6-trifluoromethyl-3-pyridinecarboxylic acid, 2-Chloro-6-(trifluoromethyl)-3-pyridinecarboxylic acid, 3-Pyridinecarboxylic acid, 2-chloro-6-(trifluoromethyl)-, 2-chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid

2-Chloro-6-(trifluoromethyl)nicotinic acid (CAS 280566-45-2) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C7H3ClF3NO2 and a molecular weight of 225.552 g/mol. Key properties include a melting point of 120 °C, a boiling point of 271.3±40.0 °C at 760 mmHg, a density of 1.6±0.1 g/cm3 and a flash point of 117.9±27.3 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 280566-45-2
Jingsj CID: J-16527-5
Molecular Formula: C₇H₃ClF₃NO₂
Molecular Weight: 225.552 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	120 °C
Boiling Point	271.3±40.0 °C at 760 mmHg
Density	1.6±0.1 g/cm3
Flash Point	117.9±27.3 °C
Exact Mass	224.980438
PSA	50.19000
LogP	2.17
Vapor Pressure	0.0±0.6 mmHg at 25°C
Refractive Index	1.497

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed
H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Customs & Trade Information

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 2-Chloro-6-(trifluoromethyl)nicotinic acid?

The CAS number of 2-Chloro-6-(trifluoromethyl)nicotinic acid is 280566-45-2.

What are the molecular formula and molecular weight of 2-Chloro-6-(trifluoromethyl)nicotinic acid?

2-Chloro-6-(trifluoromethyl)nicotinic acid has molecular formula C7H3ClF3NO2 and molecular weight 225.552 g/mol.

Is 2-Chloro-6-(trifluoromethyl)nicotinic acid hazardous?

2-Chloro-6-(trifluoromethyl)nicotinic acid has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.

What are the upstream and downstream products of 2-Chloro-6-(trifluoromethyl)nicotinic acid?

For 2-Chloro-6-(trifluoromethyl)nicotinic acid, Upstream Products: Carbon dioxide, 2-Chloro-6-(trifluoromethyl)pyridine; Downstream Products: Methyl 2-chloro-6-(trifluoromethyl)nicotinate, 2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-ol, 2-amino-6-(trifluoromethyl)nicotinic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2-Chloro-6-(trifluoromethyl)nicotinic acid (CAS 280566-45-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-16527-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.