4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol

Also known as: JANEX-1, Janex 1, WHI-P131, WHI P131, JAK3 Inhibitor I, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol, Phenol, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-

4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol (CAS 202475-60-3) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C16H15N3O3 and a molecular weight of 297.309 g/mol. Key properties include a boiling point of 468.1±40.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 236.9±27.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 202475-60-3
Jingsj CID: J-1639-7
Molecular Formula: C₁₆H₁₅N₃O₃
Molecular Weight: 297.309 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	468.1±40.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	236.9±27.3 °C
Exact Mass	297.111328
PSA	76.50000
LogP	2.73
Appearance	light yellow solid
Vapor Pressure	0.0±1.2 mmHg at 25°C
Refractive Index	1.689
Storage Conditions	-20℃

Activity & Biological Data

Target	JAK3:78 μM (IC50)
Additional Information	[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. [2]. Oh YB, et al. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med. 2013 May 17;45:e23 [3]. Uckun FM, et al. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline. Clin Cancer Res. 1999 Oct;5(10):2954-62. [4]. Xia F, et al. IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma. Autophagy. 2018;14(3):450-464.

Target

JAK3:78 μM (IC50)

Additional Information

[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. [2]. Oh YB, et al. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med. 2013 May 17;45:e23 [3]. Uckun FM, et al. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline. Clin Cancer Res. 1999 Oct;5(10):2954-62. [4]. Xia F, et al. IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma. Autophagy. 2018;14(3):450-464.

Frequently Asked Questions

What is the CAS number of 4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol?

The CAS number of 4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol is 202475-60-3.

What are the molecular formula and molecular weight of 4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol?

4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol has molecular formula C16H15N3O3 and molecular weight 297.309 g/mol.

What are the upstream and downstream products of 4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol?

For 4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol, Upstream Products: 4-Aminophenol, 4-Chloro-6,7-dimethoxyquinazoline, 2-Amino-4,5-dimethoxybenzamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol (CAS 202475-60-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1639-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.