3-Deazaadenosine

Also known as: 3-Deaza-D-adenosine, 3-Deaza-rA, C3-Ado, 4-Amino-1-(β-D-ribofuranosyl)-1H-imidazo[4,5-c]pyridine, 1-(β-D-Ribofuranosyl)-1H-imidazo[4,5-c]pyridin-4-amine, NSC 167897, Adenosine, 3-deaza-

3-Deazaadenosine (CAS 6736-58-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C11H14N4O4 and a molecular weight of 266.253 g/mol. Key properties include a melting point of 228-229ºC, a boiling point of 665.7±65.0 °C at 760 mmHg, a density of 1.9±0.1 g/cm3 and a flash point of 356.4±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 6736-58-9
Jingsj CID: J-1606-8
Molecular Formula: C₁₁H₁₄N₄O₄
Molecular Weight: 266.253 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	228-229ºC
Boiling Point	665.7±65.0 °C at 760 mmHg
Density	1.9±0.1 g/cm3
Flash Point	356.4±34.3 °C
Exact Mass	266.101501
PSA	126.65000
LogP	0.18
Vapor Pressure	0.0±2.1 mmHg at 25°C
Refractive Index	1.834
Storage Conditions	2-8°C
Additional Property	H2O: 10 mg/mL with heating to 60 °C

Activity & Biological Data

Target	IC50: 0.15 (HIV-1, A012 isolate), 0.20 µM (HIV-1, A018 isolate)[1] Ki: 3.9 µM (S-adenosylhomocysteine hydrolase)[1]
Additional Information	[1]. Gordon RK, et al. Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270(17):3507-17. [2]. Jeong SY, et al. 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. J Biol Chem. 1999 Jul 2;274(27):18981-8. [3]. Sedding DG, et al. 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling. Circ Res. 2009 May 22;104(10):1192-200.

Target

IC50: 0.15 (HIV-1, A012 isolate), 0.20 µM (HIV-1, A018 isolate)[1] Ki: 3.9 µM (S-adenosylhomocysteine hydrolase)[1]

Additional Information

[1]. Gordon RK, et al. Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270(17):3507-17. [2]. Jeong SY, et al. 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. J Biol Chem. 1999 Jul 2;274(27):18981-8. [3]. Sedding DG, et al. 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling. Circ Res. 2009 May 22;104(10):1192-200.

Frequently Asked Questions

What is the CAS number of 3-Deazaadenosine?

The CAS number of 3-Deazaadenosine is 6736-58-9.

What are the molecular formula and molecular weight of 3-Deazaadenosine?

3-Deazaadenosine has molecular formula C11H14N4O4 and molecular weight 266.253 g/mol.

What are the upstream and downstream products of 3-Deazaadenosine?

For 3-Deazaadenosine, Upstream Products: 1H-Imidazo[4,5-c]pyridin-4-amine, Uridine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "3-Deazaadenosine (CAS 6736-58-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1606-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.