L-741,626

Also known as: 1-(indol-3-ylmethyl)-4-hydroxy-4-(p-chlorophenyl)piperidine, 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole, 4-(4-CHLOROPHENYL)-1-(1H-INDOL-3-YL METHYL)PIPERIDIN-4-OL, 4-(4-Chlorophenyl)-1-(1H-indol-3-ylmethyl)-4-piperidinol, 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidin-4-ol, 4-Piperidinol, 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)-, 4-Piperidinol,4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl), L 741,626, L-741,626, D2 antagonist, L-741626, 10 mM in DMSO, receptor,selective,TNF-α,Inhibitor,dopamine,Dopamine Receptor,production,L-741626,L 741626,L741626,inhibit

L-741,626 (CAS 81226-60-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H21ClN2O and a molecular weight of 340.84700 g/mol. Key properties include a boiling point of 548.8ºC at 760 mmHg, a density of 1.311g/cm3 and a flash point of 285.7ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 81226-60-0
Jingsj CID: J-1601597-7
Molecular Formula: C₂₀H₂₁ClN₂O
Molecular Weight: 340.84700 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	548.8ºC at 760 mmHg
Density	1.311g/cm3
Flash Point	285.7ºC
Exact Mass	340.13400
PSA	39.26000
LogP	4.24280
Refractive Index	1.686

Activity & Biological Data

Target	Ki: 2.4 nM (human D2 receptor), 100 nM (human D3 receptor), 220 nM (human D4 receptor)[1]
Additional Information	[1]. Lewitus GM, et al. Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. 2016 May 4;90(3):483-91. [2]. Grundt P, et al. Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorg Med Chem Lett. 2007 Feb 1;17(3):745-9. [3]. Koffarnus MN, et al. The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats. Psychopharmacology (Berl). 2009 Apr;203(2):317-27. [4]. Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2.

Target

Ki: 2.4 nM (human D2 receptor), 100 nM (human D3 receptor), 220 nM (human D4 receptor)[1]

Additional Information

[1]. Lewitus GM, et al. Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. 2016 May 4;90(3):483-91. [2]. Grundt P, et al. Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorg Med Chem Lett. 2007 Feb 1;17(3):745-9. [3]. Koffarnus MN, et al. The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats. Psychopharmacology (Berl). 2009 Apr;203(2):317-27. [4]. Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2.

Frequently Asked Questions

What is the CAS number of L-741,626?

The CAS number of L-741,626 is 81226-60-0.

What are the molecular formula and molecular weight of L-741,626?

L-741,626 has molecular formula C20H21ClN2O and molecular weight 340.84700 g/mol.

What are the upstream and downstream products of L-741,626?

For L-741,626, Upstream Products: Indole, 4-(4-Chlorophenyl)piperidin-4-ol, Gramine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "L-741,626 (CAS 81226-60-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1601597-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.