β-Propiolactone
Also known as: 2-Oxetanone, 3-Hydroxypropanoic Acid b-Lactone, Hydracrylic Acid b-Lactone, Hydracrylic acid β-lactone, Oxetan-2-one, beta-propiolactone, propiolactone, β-Propionolactone, b-Propionolactone, EINECS 200-340-1, MFCD00005169
β-Propiolactone (CAS 57-57-8) is a compound in the Esters category listed in the Jingsj chemical database. It has the molecular formula C3H4O2 and a molecular weight of 72.063 g/mol. Key properties include a melting point of −33 °C(lit.), a boiling point of 162.0±0.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 35.0±16.1 °C. It is classified under GHS with signal word Danger and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H330 — Fatal if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 57-57-8
- Jingsj CID
- J-15321-2
- Molecular Formula
- C3H4O2
- Molecular Weight
- 72.063 g/mol
- Category
- Esters
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | −33 °C(lit.) |
|---|---|
| Boiling Point | 162.0±0.0 °C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
| Flash Point | 35.0±16.1 °C |
| Exact Mass | 72.021126 |
| PSA | 26.30000 |
| LogP | -1.33 |
| Vapor Pressure | 2.2±0.3 mmHg at 25°C |
| Refractive Index | 1.445 |
| Additional Property | 37 g/100 mL |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H330 — Fatal if inhaled
- H350 — May cause cancer
Activity & Biological Data
| Target | SARS-CoV-2[1] |
|---|---|
| Additional Information | [1]. Roberts A, et al. Immunogenicity and protective efficacy in mice and hamsters of a β-propiolactone inactivated whole virus SARS-CoV vaccine. Viral Immunol. 2010 Oct;23(5):509-19 [2]. Kulkarni R, et al. Anti-SARS-CoV-2 IgG antibody response among Indian COVID-19 patients using β-propiolactone-inactivated, whole virus-based indirect ELISA. J Virol Methods. 2021 Jan;287:113996. |
Customs & Trade Information
| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of β-Propiolactone?
The CAS number of β-Propiolactone is 57-57-8.
What are the molecular formula and molecular weight of β-Propiolactone?
β-Propiolactone has molecular formula C3H4O2 and molecular weight 72.063 g/mol.
Is β-Propiolactone hazardous?
β-Propiolactone has GHS signal word Danger and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H330 — Fatal if inhaled.
What are the upstream and downstream products of β-Propiolactone?
For β-Propiolactone, Upstream Products: Ethylene oxide, cyclopropanone, 3-Bromopropanoic acid; Downstream Products: Triethyl 3-phosphonopropionate, 3-(2-Benzothiazolylthio)propionic acid, 3-Hydroxypropionic acid.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "β-Propiolactone (CAS 57-57-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-15321-2 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.