Canagliflozin

Also known as: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol, (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, TA 7284, JNJ 28431754, UNII-6S49DGR869

Canagliflozin (CAS 842133-18-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C24H25FO5S and a molecular weight of 444.516 g/mol. Key properties include a boiling point of 642.9±55.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 342.6±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 842133-18-0
Jingsj CID: J-1523195-5
Molecular Formula: C₂₄H₂₅FO₅S
Molecular Weight: 444.516 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	642.9±55.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	342.6±31.5 °C
Exact Mass	444.140686
PSA	118.39000
LogP	5.34
Vapor Pressure	0.0±2.0 mmHg at 25°C
Refractive Index	1.639
Storage Conditions	-20°C

Activity & Biological Data

Target	IC50: 2/3.7/4.4 nM (m/r/hSGLT2, in CHOK cells)[1]
Additional Information	[1]. Liang Y, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555. [2]. Kobuchi S, et al. A validated LC-MS/MS method for the determination of canagliflozin, a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, in a lower volume of rat plasma: application to pharmacokinetic studies in rats. Biomed Chromatogr. 2016 Oct;30(10):1549-55.

Target

IC50: 2/3.7/4.4 nM (m/r/hSGLT2, in CHOK cells)[1]

Additional Information

[1]. Liang Y, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555. [2]. Kobuchi S, et al. A validated LC-MS/MS method for the determination of canagliflozin, a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, in a lower volume of rat plasma: application to pharmacokinetic studies in rats. Biomed Chromatogr. 2016 Oct;30(10):1549-55.

Frequently Asked Questions

What is the CAS number of Canagliflozin?

The CAS number of Canagliflozin is 842133-18-0.

What are the molecular formula and molecular weight of Canagliflozin?

Canagliflozin has molecular formula C24H25FO5S and molecular weight 444.516 g/mol.

What are the upstream and downstream products of Canagliflozin?

For Canagliflozin, Upstream Products: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol tetraacetate, Methyl 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucopyranoside, alpha-D-glucose.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Canagliflozin (CAS 842133-18-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1523195-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.