Methotrexate dimethyl ester

Also known as: Dimethyl methotrexate, Methotrexate EP Impurity J, Methotrexate Impurity 10, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid dimethyl ester, (S)-Dimethyl 2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate

Methotrexate dimethyl ester (CAS 34378-65-9) is a compound in the Esters category listed in the Jingsj chemical database. It has the molecular formula C22H26N8O5 and a molecular weight of 482.49200 g/mol. Key property: a melting point of 134-140°C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 34378-65-9
Jingsj CID: J-1516066-5
Molecular Formula: C₂₂H₂₆N₈O₅
Molecular Weight: 482.49200 g/mol
Category: Esters
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	134-140°C
Exact Mass	482.20300
PSA	188.54000
LogP	1.99850

Frequently Asked Questions

What is the CAS number of Methotrexate dimethyl ester?

The CAS number of Methotrexate dimethyl ester is 34378-65-9.

What are the molecular formula and molecular weight of Methotrexate dimethyl ester?

Methotrexate dimethyl ester has molecular formula C22H26N8O5 and molecular weight 482.49200 g/mol.

What are the upstream and downstream products of Methotrexate dimethyl ester?

For Methotrexate dimethyl ester, Downstream Products: 7-Hydroxymethotrexate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Methotrexate dimethyl ester (CAS 34378-65-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1516066-5 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.