Resibufogenin

Also known as: Bufogenin, Respigon, RBG, 14,15β-Epoxy-3β-hydroxy-5β-bufa-20,22-dienolide, (3β,5β,15β)-14,15-Epoxy-3-hydroxybufa-20,22-dienolide

Resibufogenin (CAS 465-39-4) is a compound in the Esters category listed in the Jingsj chemical database. It has the molecular formula C24H32O4 and a molecular weight of 384.509 g/mol. Key properties include a melting point of 155ºC, a boiling point of 554.9±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 190.7±23.6 °C. It is classified under GHS with signal word Danger and hazard statements H300, H310 and H330 — Fatal if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 465-39-4
Jingsj CID: J-1500-6
Molecular Formula: C₂₄H₃₂O₄
Molecular Weight: 384.509 g/mol
Category: Esters
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	155ºC
Boiling Point	554.9±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	190.7±23.6 °C
Exact Mass	384.230072
PSA	62.97000
LogP	2.89
Vapor Pressure	0.0±3.4 mmHg at 25°C
Refractive Index	1.603

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H300
H310
H330 — Fatal if inhaled

Activity & Biological Data

Additional Information	[1]. Hao S, et al. Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons. Toxicol In Vitro. 2011 Dec;25(8):1644-53. [2]. Uddin MN, et al. Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia. Hypertens Pregnancy. 2012;31(1):70-8. [3]. Ichikawa M, et al. Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. PLoS One. 2015 Jun 29;10(6):e0129851. [4]. Hao S, et al. Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neurosci Lett. 2011 Aug 26;501(2):112-6. [5]. Zheng J, et al. Novel microbial transformation of resibufogenin by Absidia coerules. Nat Prod Commun. 2011 Nov;6(11):1581-4. [6]. Xin XL, et al. Novel microbial transformation of resibufogenin by Fusarium solani. J Asian Nat Prod Res. 2011 Sep;13(9):831-7.

Additional Information

[1]. Hao S, et al. Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons. Toxicol In Vitro. 2011 Dec;25(8):1644-53. [2]. Uddin MN, et al. Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia. Hypertens Pregnancy. 2012;31(1):70-8. [3]. Ichikawa M, et al. Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. PLoS One. 2015 Jun 29;10(6):e0129851. [4]. Hao S, et al. Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neurosci Lett. 2011 Aug 26;501(2):112-6. [5]. Zheng J, et al. Novel microbial transformation of resibufogenin by Absidia coerules. Nat Prod Commun. 2011 Nov;6(11):1581-4. [6]. Xin XL, et al. Novel microbial transformation of resibufogenin by Fusarium solani. J Asian Nat Prod Res. 2011 Sep;13(9):831-7.

Frequently Asked Questions

What is the CAS number of Resibufogenin?

The CAS number of Resibufogenin is 465-39-4.

What are the molecular formula and molecular weight of Resibufogenin?

Resibufogenin has molecular formula C24H32O4 and molecular weight 384.509 g/mol.

Is Resibufogenin hazardous?

Resibufogenin has GHS signal word Danger and hazard statements H300; H310; H330 — Fatal if inhaled.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Resibufogenin (CAS 465-39-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1500-6 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.