Rofecoxib

Also known as: Vioxx, MK-0966, Ceoxx, Ceeoxx, 4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone, 4-(4-Methylsulfonylphenyl)-3-phenyl-5H-furan-2-one

Rofecoxib (CAS 162011-90-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C17H14O4S and a molecular weight of 314.356 g/mol. Key properties include a melting point of 207°C, a boiling point of 577.6±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 303.1±30.1 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 162011-90-7
Jingsj CID: J-14971-3
Molecular Formula: C₁₇H₁₄O₄S
Molecular Weight: 314.356 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	207°C
Boiling Point	577.6±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	303.1±30.1 °C
Exact Mass	314.061279
PSA	68.82000
LogP	1.34
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.619
Storage Conditions	Refrigerator

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	Human COX-2:18 nM (IC50, in Chinese hamster ovary cells) Human COX-2:26 nM (IC50, in human osteosarcoma cells)
Additional Information	[1]. Rofecoxib, et al. Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther. 1999 Aug;290(2):551-60. [2]. Liu NN, et al. Rofecoxib inhibits retinal neovascularization via down regulation of cyclooxygenase-2 and vascular endothelial growth factor expression. Clin Exp Ophthalmol. 2015 Jul;43(5):458-65. [3]. Stoppoloni D, et al. Synergistic effect of gefitinib and rofecoxib in mesothelioma cells. Mol Cancer. 2010 Feb 2;9:27.

Target

Human COX-2:18 nM (IC50, in Chinese hamster ovary cells) Human COX-2:26 nM (IC50, in human osteosarcoma cells)

Additional Information

[1]. Rofecoxib, et al. Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther. 1999 Aug;290(2):551-60. [2]. Liu NN, et al. Rofecoxib inhibits retinal neovascularization via down regulation of cyclooxygenase-2 and vascular endothelial growth factor expression. Clin Exp Ophthalmol. 2015 Jul;43(5):458-65. [3]. Stoppoloni D, et al. Synergistic effect of gefitinib and rofecoxib in mesothelioma cells. Mol Cancer. 2010 Feb 2;9:27.

Customs & Trade Information

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Rofecoxib?

The CAS number of Rofecoxib is 162011-90-7.

What are the molecular formula and molecular weight of Rofecoxib?

Rofecoxib has molecular formula C17H14O4S and molecular weight 314.356 g/mol.

Is Rofecoxib hazardous?

Rofecoxib has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Rofecoxib?

For Rofecoxib, Upstream Products: 2-Bromo-1-[4-(methylsulfonyl)phenyl]ethanone, Ethyl bromoacetate, Phenylboronic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Rofecoxib (CAS 162011-90-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-14971-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.