(5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
Also known as: JNJ-7777120, JNJ 7777120, 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine, (5-Chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)methanone, Methanone, (5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-, Piperazine, 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methyl-, CS-593
(5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone (CAS 459168-41-3) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C14H16ClN3O and a molecular weight of 277.749 g/mol. Key properties include a boiling point of 477.0±45.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 242.3±28.7 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 459168-41-3
- Jingsj CID
- J-1495679-7
- Molecular Formula
- C14H16ClN3O
- Molecular Weight
- 277.749 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 477.0±45.0 °C at 760 mmHg |
|---|---|
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 242.3±28.7 °C |
| Exact Mass | 277.098175 |
| PSA | 39.34000 |
| LogP | 0.69 |
| Appearance | solid | white |
| Vapor Pressure | 0.0±1.2 mmHg at 25°C |
| Refractive Index | 1.656 |
| Storage Conditions | Store at +4°C |
| Additional Property | H2O: insoluble |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Additional Information | [1]. Jablonowski JA, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003 Sep 11;46(19):3957-3960. [2]. Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ-7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-316. [3]. Thurmond RL, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-413. |
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Frequently Asked Questions
What is the CAS number of (5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone?
The CAS number of (5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone is 459168-41-3.
What are the molecular formula and molecular weight of (5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone?
(5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone has molecular formula C14H16ClN3O and molecular weight 277.749 g/mol.
Is (5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone hazardous?
(5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
What are the upstream and downstream products of (5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone?
For (5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone, Upstream Products: 1-Methylpiperazine, 5-Chloro-1H-indole-2-carboxylic acid.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "(5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone (CAS 459168-41-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1495679-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.