Hydroxypioglitazone

Also known as: Hydroxy Pioglitazone, Hydroxy Pioglitazone (M-IV), Leriglitazone, Pioglitazone M4 Metabolite, Pioglitazone Impurity 18, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione, 5-(4-{2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione

Hydroxypioglitazone (CAS 146062-44-4) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C19H20N2O4S and a molecular weight of 372.438 g/mol. Key properties include a melting point of 157-158ºC, a boiling point of 627.6±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 333.4±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 146062-44-4
Jingsj CID: J-1474-4
Molecular Formula: C₁₉H₂₀N₂O₄S
Molecular Weight: 372.438 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	157-158ºC
Boiling Point	627.6±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	333.4±31.5 °C
Exact Mass	372.114380
PSA	113.82000
LogP	1.11
Vapor Pressure	0.0±1.9 mmHg at 25°C
Refractive Index	1.628

Activity & Biological Data

Target	Ki: 1.2 μM (PPARγ LBD); EC: 680 nM (PPARγ LBD) (Leriglitazone)[1]
Additional Information	[1]. Mosure SA,et al. Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone. J Med Chem. 2019 Feb 28;62(4):2008-2023.

Frequently Asked Questions

What is the CAS number of Hydroxypioglitazone?

The CAS number of Hydroxypioglitazone is 146062-44-4.

What are the molecular formula and molecular weight of Hydroxypioglitazone?

Hydroxypioglitazone has molecular formula C19H20N2O4S and molecular weight 372.438 g/mol.

What are the upstream and downstream products of Hydroxypioglitazone?

For Hydroxypioglitazone, Upstream Products: 5-Acetyl-2-methylpyridine, 1-(6-methylpyridin-3-yl)ethanol, Methyl 6-methylnicotinate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Hydroxypioglitazone (CAS 146062-44-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1474-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.