Probenecid

Also known as: 4-(Dipropylsulfamoyl)benzoic acid, 4-[(Dipropylamino)sulfonyl]benzoic acid, Benemid, Benuryl, Probalan, Probecid, p-(Dipropylsulfamoyl)benzoic acid, Apurina, Proben, Probexin

Probenecid (CAS 57-66-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C13H19NO4S and a molecular weight of 285.359 g/mol. Key properties include a melting point of 194-196°C, a boiling point of 438.0±47.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 218.7±29.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 57-66-9
Jingsj CID: J-14655-4
Molecular Formula: C₁₃H₁₉NO₄S
Molecular Weight: 285.359 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	194-196°C
Boiling Point	438.0±47.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	218.7±29.3 °C
Exact Mass	285.103485
PSA	83.06000
LogP	3.30
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.542
Stability	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Additional Property	<0.1 g/100 mL at 20 ºC

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	TRPV2[1]
Additional Information	[1]. Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53(1):134-44. [2]. Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. [3]. Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6(5):e20123.

Target

TRPV2[1]

Additional Information

[1]. Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53(1):134-44. [2]. Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. [3]. Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6(5):e20123.

Customs & Trade Information

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Frequently Asked Questions

What is the CAS number of Probenecid?

The CAS number of Probenecid is 57-66-9.

What are the molecular formula and molecular weight of Probenecid?

Probenecid has molecular formula C13H19NO4S and molecular weight 285.359 g/mol.

Is Probenecid hazardous?

Probenecid has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Probenecid?

For Probenecid, Upstream Products: 4-(Chlorosulfonyl)benzoic acid, Dipropylamine, p-Toluenesulfonamide; Downstream Products: 4-[(Dipropylamino)sulfonyl]benzene-1-carbonyl chloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Probenecid (CAS 57-66-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-14655-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.