Thalidomide

Also known as: 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Contergan, Softenon, Thalomide, Neosedyn, Neurodyn, Pomalidomide Impurity 9, UNII:4Z8R6ORS6L

Thalidomide (CAS 50-35-1) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C13H10N2O4 and a molecular weight of 258.229 g/mol. Key properties include a melting point of 269-271°C, a boiling point of 509.7±43.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 262.1±28.2 °C. It is classified under GHS with signal word Danger and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 50-35-1
Jingsj CID: J-14325-5
Molecular Formula: C₁₃H₁₀N₂O₄
Molecular Weight: 258.229 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	269-271°C
Boiling Point	509.7±43.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	262.1±28.2 °C
Exact Mass	258.064056
PSA	83.55000
LogP	0.54
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.646
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Additional Property	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.6 mg/mL \| <0.1 g/100 mL at 22 ºC

GHS Safety & Compliance

Irritant / Health HazardSignal word: Danger

H302 — Harmful if swallowed

Activity & Biological Data

Target	Kd: ∼250 nM (CRL4CRBN)[1]
Additional Information	[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [2]. Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453. [3]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.

Target

Kd: ∼250 nM (CRL4CRBN)[1]

Additional Information

[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [2]. Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453. [3]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.

Customs & Trade Information

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Thalidomide?

The CAS number of Thalidomide is 50-35-1.

What are the molecular formula and molecular weight of Thalidomide?

Thalidomide has molecular formula C13H10N2O4 and molecular weight 258.229 g/mol.

Is Thalidomide hazardous?

Thalidomide has GHS signal word Danger and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Thalidomide?

For Thalidomide, Upstream Products: N-Phthalyl-DL-glutamic Anhydride, Phthalic anhydride, L-Glutamine; Downstream Products: (R)-(+)-Thalidomide, (S)-Thalidomide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Thalidomide (CAS 50-35-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-14325-5 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.