Tazarotene

Also known as: Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate, Ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate, Ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate, 6-[(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester, Tazorac, Zorac, Avage, AGN 190168, 6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic Acid Ethyl Ester

Tazarotene (CAS 118292-40-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H21NO2S and a molecular weight of 351.462 g/mol. Key properties include a melting point of 97-98ºC, a boiling point of 499.8±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 256.1±28.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 118292-40-3
Jingsj CID: J-1401443-7
Molecular Formula: C₂₁H₂₁NO₂S
Molecular Weight: 351.462 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	97-98ºC
Boiling Point	499.8±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	256.1±28.7 °C
Exact Mass	351.129303
PSA	64.49000
LogP	6.22
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.625
Storage Conditions	Store at +4°C

Activity & Biological Data

Additional Information	[1]. Talpur R, et al. Efficacy and safety of topical tazarotene: a review. Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):195-210. [2]. Nagpal S, et al. Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acidreceptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis. Cell Growth Differ. 1996 Dec;7(12):1783-91. [3]. Tang-Liu DD, et al. Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis. Clin Pharmacokinet. 1999 Oct;37(4):273-87.

Additional Information

[1]. Talpur R, et al. Efficacy and safety of topical tazarotene: a review. Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):195-210. [2]. Nagpal S, et al. Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acidreceptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis. Cell Growth Differ. 1996 Dec;7(12):1783-91. [3]. Tang-Liu DD, et al. Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis. Clin Pharmacokinet. 1999 Oct;37(4):273-87.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Tazarotene?

The CAS number of Tazarotene is 118292-40-3.

What are the molecular formula and molecular weight of Tazarotene?

Tazarotene has molecular formula C21H21NO2S and molecular weight 351.462 g/mol.

What are the upstream and downstream products of Tazarotene?

For Tazarotene, Upstream Products: 6-Ethynyl-4,4-dimethylthiochroman, Ethyl 6-chloronicotinate, Ethanol; Downstream Products: Benzoyl peroxide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tazarotene (CAS 118292-40-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1401443-7 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.