Mefloquine

Also known as: Mephaquin, Mefloquin, Ro 21-5998, WR-142490, (R*,S*)-(±)-a-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol

Mefloquine (CAS 53230-10-7) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C17H16F6N2O and a molecular weight of 378.31200 g/mol. Key properties include a melting point of 242-244ºC, a boiling point of 415.7ºC at 760mmHg, a density of 1.383g/cm3 and a flash point of 205.2ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 53230-10-7
Jingsj CID: J-1381604-3
Molecular Formula: C₁₇H₁₆F₆N₂O
Molecular Weight: 378.31200 g/mol
Category: Organohalogen Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	242-244ºC
Boiling Point	415.7ºC at 760mmHg
Density	1.383g/cm3
Flash Point	205.2ºC
Exact Mass	378.11700
PSA	45.15000
LogP	4.77670
Refractive Index	1.519
Storage Conditions	Refrigerator, Under Inert Atmosphere

Activity & Biological Data

Additional Information	[1]. Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6. [2]. Yan KH, et al. Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545. [3]. Kaho Shionoya, et al. Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro. Front Microbiol. 2021 Apr 30;12:651403. [4]. Rafael Pacheco-Costa, et al. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 Sep;114:22-31.

Additional Information

[1]. Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6. [2]. Yan KH, et al. Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545. [3]. Kaho Shionoya, et al. Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro. Front Microbiol. 2021 Apr 30;12:651403. [4]. Rafael Pacheco-Costa, et al. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 Sep;114:22-31.

Frequently Asked Questions

What is the CAS number of Mefloquine?

The CAS number of Mefloquine is 53230-10-7.

What are the molecular formula and molecular weight of Mefloquine?

Mefloquine has molecular formula C17H16F6N2O and molecular weight 378.31200 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Mefloquine (CAS 53230-10-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1381604-3 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.