2-(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid

Also known as: GW0742, GW 0742, GW 610742, GWdelta 0742, [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid, {4-[({2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid, 2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid, 4-[2-(3-fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]-2-methyl-phenoxy-acetic acid, Acetic acid, 2-[4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-

2-(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid (CAS 317318-84-6) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C21H17F4NO3S2 and a molecular weight of 471.488 g/mol. Key properties include a melting point of 134.5-135.5 °C, a boiling point of 591.5±60.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 311.5±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 317318-84-6
Jingsj CID: J-1363894-3
Molecular Formula: C₂₁H₁₇F₄NO₃S₂
Molecular Weight: 471.488 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	134.5-135.5 °C
Boiling Point	591.5±60.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	311.5±32.9 °C
Exact Mass	471.058594
PSA	112.96000
LogP	6.57
Appearance	solid \| white
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.609
Storage Conditions	2-8°C
Additional Property	DMSO: >5 mg/mL

Activity & Biological Data

Target	PPARδ:1 nM (EC50) PPARα:1.1 μM (EC50) PPARγ:2 μM (EC50)
Additional Information	[1]. Sznaidman ML, et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21. [2]. Smith SA, et al. Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons. J Neurosci Res. 2004 Jul 15;77(2):240-9. [3]. Galuppo M, et al. GW0742, a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice. Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):1033-46. [4]. Kuo SC, et al. Activation of receptors δ (PPARδ) by agonist (GW0742) may enhance lipid metabolism in heart both in vivo and in vitro. Horm Metab Res. 2013 Nov;45(12):880-6.

Target

PPARδ:1 nM (EC50) PPARα:1.1 μM (EC50) PPARγ:2 μM (EC50)

Additional Information

[1]. Sznaidman ML, et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21. [2]. Smith SA, et al. Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons. J Neurosci Res. 2004 Jul 15;77(2):240-9. [3]. Galuppo M, et al. GW0742, a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice. Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):1033-46. [4]. Kuo SC, et al. Activation of receptors δ (PPARδ) by agonist (GW0742) may enhance lipid metabolism in heart both in vivo and in vitro. Horm Metab Res. 2013 Nov;45(12):880-6.

Frequently Asked Questions

What is the CAS number of 2-(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid?

The CAS number of 2-(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid is 317318-84-6.

What are the molecular formula and molecular weight of 2-(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid?

2-(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid has molecular formula C21H17F4NO3S2 and molecular weight 471.488 g/mol.

What are the upstream and downstream products of 2-(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid?

For 2-(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid, Upstream Products: 1-(4-Hydroxy-3-methylphenyl)ethanone, Methyl 2-(4-hydroxy-2-methylphenoxy)acetate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2-(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid (CAS 317318-84-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1363894-3 (accessed 2026-11-09).

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