Darifenacin

Also known as: UK-88525, UK 88525, UK88525, (S)-1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide, 2-{(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide, 3-Pyrrolidineacetamide, 1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-, (3S)-

Darifenacin (CAS 133099-04-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C28H30N2O2 and a molecular weight of 426.550 g/mol. Key properties include a boiling point of 614.3±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 325.3±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 133099-04-4
Jingsj CID: J-1347412-9
Molecular Formula: C₂₈H₃₀N₂O₂
Molecular Weight: 426.550 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	614.3±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	325.3±31.5 °C
Exact Mass	426.230713
PSA	55.56000
LogP	4.50
Vapor Pressure	0.0±1.8 mmHg at 25°C
Refractive Index	1.624
Storage Conditions	2-8℃

Activity & Biological Data

Additional Information	[1]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418. [2]. Miller DW, et al. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn, 2011, 30(8), 1633-1638. [3]. Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol, 2007, 52(3), 842-847. [4]. Lu XZ, et al. Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin-dependent protein kinase II pathway. Br J Pharmacol. 2015 Dec;172(23):5619-33. [5]. Yu H, et al.Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation. Sci Rep. 2017 Jan 19;7:40802.

Additional Information

[1]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418. [2]. Miller DW, et al. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn, 2011, 30(8), 1633-1638. [3]. Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol, 2007, 52(3), 842-847. [4]. Lu XZ, et al. Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin-dependent protein kinase II pathway. Br J Pharmacol. 2015 Dec;172(23):5619-33. [5]. Yu H, et al.Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation. Sci Rep. 2017 Jan 19;7:40802.

Frequently Asked Questions

What is the CAS number of Darifenacin?

The CAS number of Darifenacin is 133099-04-4.

What are the molecular formula and molecular weight of Darifenacin?

Darifenacin has molecular formula C28H30N2O2 and molecular weight 426.550 g/mol.

What are the upstream and downstream products of Darifenacin?

For Darifenacin, Upstream Products: Darifenacin oxidized impurity, Darifenacin hydrobromide, 5-(2-Bromoethyl)-2,3-dihydrobenzofuran; Downstream Products: Darifenacin hydrobromide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Darifenacin (CAS 133099-04-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1347412-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.