Tyrphostin A9
Also known as: Malonoben, AG 17, SF 6847, Tyrphostin 9, Tyrphostin AG17, NSC 242557, RG 50872, GCP 5126, Malonobene, 3,5-Di-tert-butyl-4-hydroxybenzylidenemalononitrile, 2-(3,5-Di-tert-butyl-4-hydroxybenzylidene)malononitrile
Tyrphostin A9 (CAS 10537-47-0) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C18H22N2O and a molecular weight of 282.380 g/mol. Key properties include a melting point of 141-143℃ (ethanol ), a boiling point of 386.8±37.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 187.7±26.5 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H311 — Toxic in contact with skin and H331 — Toxic if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 10537-47-0
- Jingsj CID
- J-1347205-2
- Molecular Formula
- C18H22N2O
- Molecular Weight
- 282.380 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 141-143℃ (ethanol ) |
|---|---|
| Boiling Point | 386.8±37.0 °C at 760 mmHg |
| Density | 1.1±0.1 g/cm3 |
| Flash Point | 187.7±26.5 °C |
| Exact Mass | 282.173218 |
| PSA | 67.81000 |
| LogP | 4.81 |
| Vapor Pressure | 0.0±0.9 mmHg at 25°C |
| Refractive Index | 1.555 |
| Additional Property | ethanol: 20 mg/mL |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H311 — Toxic in contact with skin
- H331 — Toxic if inhaled
Activity & Biological Data
| Additional Information | [1]. Park SJ, Park YJ, Shin JH, et al. A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Biochem Biophys Res Commun. 2011 May 13;408(3):465-70. [2]. Richard F. Loeser, Christopher B. Forsyth, Allen M. Samarel et al. Fibronectin Fragment Activation of Proline-rich Tyrosine Kinase PYK2 Mediates Integrin Signals Regulating Collagenase-3 Expression by Human Chondrocytes through a Protein Kinase C-dependent Pathway. The Journal of Biological Chemistry, 2003, 278, 24577-24585. [3]. Michele Fuortes, Maxine Melchior, Hyunsil Han, et al. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. J Clin Invest. 1999;104(3):327-335. [4]. Johan Thyberg . Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. European Journal of Cell Biology.1998,76(1): 33-42 [5]. R Marhaba, F Mary, C Pelassy, et al. Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells. The Journal of Immunology. 1996,157 (4): 1468-1473 |
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Customs & Trade Information
| HS Code | 2926909090 |
|---|---|
| Summary | HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Frequently Asked Questions
What is the CAS number of Tyrphostin A9?
The CAS number of Tyrphostin A9 is 10537-47-0.
What are the molecular formula and molecular weight of Tyrphostin A9?
Tyrphostin A9 has molecular formula C18H22N2O and molecular weight 282.380 g/mol.
Is Tyrphostin A9 hazardous?
Tyrphostin A9 has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H311 — Toxic in contact with skin; H331 — Toxic if inhaled.
What are the upstream and downstream products of Tyrphostin A9?
For Tyrphostin A9, Upstream Products: Malononitrile, 3,5-di-tert-butyl-4-hydroxybenzaldehyde.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Tyrphostin A9 (CAS 10537-47-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1347205-2 (accessed 2026-11-07).
Data for reference only; verify product details with suppliers before purchase.