Xanthohumol

Also known as: 2',4,4'-Trihydroxy-6'-methoxy-3'-prenylchalcone, (E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one, MFCD00210576

Xanthohumol (CAS 6754-58-1) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C21H22O5 and a molecular weight of 354.396 g/mol. Key properties include a melting point of 157-159ºC, a boiling point of 576.5±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 203.4±23.6 °C. It is classified under GHS with signal word Warning and hazard statements H317 — May cause an allergic skin reaction and H400 — Very toxic to aquatic life. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 6754-58-1
Jingsj CID: J-1316601-8
Molecular Formula: C₂₁H₂₂O₅
Molecular Weight: 354.396 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	157-159ºC
Boiling Point	576.5±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	203.4±23.6 °C
Exact Mass	354.146729
PSA	86.99000
LogP	5.17
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.641
Storage Conditions	2-8°C
Additional Property	ethanol: soluble10mg/mL

GHS Safety & Compliance

Irritant / Environmental HazardSignal word: Warning

H317 — May cause an allergic skin reaction
H400 — Very toxic to aquatic life

Activity & Biological Data

Additional Information	[1]. Luzak B, et al. Xanthohumol from hop cones (Humulus lupulus L.) prevents ADP-induced platelet reactivity. Arch Physiol Biochem. 2016 Nov 18:1-7. [2]. Arnaiz-Cot JJ, et al. Xanthohumol modulates calcium signaling in rat ventricular myocytes: Possible Antiarrhythmic properties. J Pharmacol Exp Ther. 2016 Nov 4. pii: jpet.116.236588. [3]. Gallo C, et al. Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation. Oncotarget. 2016 Aug 1. [4]. Chen PH, et al. The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death. Neuropharmacology. 2016 Nov;110(Pt A):362-75.

Additional Information

[1]. Luzak B, et al. Xanthohumol from hop cones (Humulus lupulus L.) prevents ADP-induced platelet reactivity. Arch Physiol Biochem. 2016 Nov 18:1-7. [2]. Arnaiz-Cot JJ, et al. Xanthohumol modulates calcium signaling in rat ventricular myocytes: Possible Antiarrhythmic properties. J Pharmacol Exp Ther. 2016 Nov 4. pii: jpet.116.236588. [3]. Gallo C, et al. Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation. Oncotarget. 2016 Aug 1. [4]. Chen PH, et al. The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death. Neuropharmacology. 2016 Nov;110(Pt A):362-75.

Frequently Asked Questions

What is the CAS number of Xanthohumol?

The CAS number of Xanthohumol is 6754-58-1.

What are the molecular formula and molecular weight of Xanthohumol?

Xanthohumol has molecular formula C21H22O5 and molecular weight 354.396 g/mol.

Is Xanthohumol hazardous?

Xanthohumol has GHS signal word Warning and hazard statements H317 — May cause an allergic skin reaction; H400 — Very toxic to aquatic life.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Xanthohumol (CAS 6754-58-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1316601-8 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.