Butein

Also known as: 2',3,4,4'-Tetrahydroxychalcone, (E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one, Chalcone, 2',3,4,4'-tetrahydroxy-, MFCD00017300, 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-, (2E)-

Butein (CAS 487-52-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C15H12O5 and a molecular weight of 272.25 g/mol. Key properties include a melting point of 216°C, a boiling point of 560.9±50.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 307.1±26.6 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 487-52-5
Jingsj CID: J-12542-8
Molecular Formula: C₁₅H₁₂O₅
Molecular Weight: 272.25 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	216°C
Boiling Point	560.9±50.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	307.1±26.6 °C
PSA	17.07000
LogP	2.66
Appearance	solid \| yellow
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.748
Additional Property	DMSO: >50 mg/mL

Activity & Biological Data

Target	EGFR
Additional Information	[1]. Er-Bin Yang et al. Butein, a Specific Protein Tyrosine Kinase Inhibitor. Biochem Biophys Res Commun, 1998 Apr 17, 245(2):435-8. [2]. Zhang L et al. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Int J Mol Med, 2015 Oct, 36(4):957-66 [3]. Hyeong Sim Choi et al. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med, 2016, 16: 122. [4]. Tang YL et al. Butein inhibits cell proliferation and induces cell cycle arrest in acute lymphoblastic leukemia via FOXO3a/p27kip1 pathway. Oncotarget, 2016 Apr 5, 7(14):18651-64.

Target

EGFR

Additional Information

[1]. Er-Bin Yang et al. Butein, a Specific Protein Tyrosine Kinase Inhibitor. Biochem Biophys Res Commun, 1998 Apr 17, 245(2):435-8. [2]. Zhang L et al. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Int J Mol Med, 2015 Oct, 36(4):957-66 [3]. Hyeong Sim Choi et al. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med, 2016, 16: 122. [4]. Tang YL et al. Butein inhibits cell proliferation and induces cell cycle arrest in acute lymphoblastic leukemia via FOXO3a/p27kip1 pathway. Oncotarget, 2016 Apr 5, 7(14):18651-64.

Frequently Asked Questions

What is the CAS number of Butein?

The CAS number of Butein is 487-52-5.

What are the molecular formula and molecular weight of Butein?

Butein has molecular formula C15H12O5 and molecular weight 272.25 g/mol.

What are the upstream and downstream products of Butein?

For Butein, Upstream Products: 2,4-Dihydroxyacetophenone, 3,4-Dihydroxybenzaldehyde, 3,4-Bis(methoxymethoxy)benzaldehyde; Downstream Products: 3',4',7-Trihydroxyisoflavone, But-2-yne, 2,4-Dihydroxyacetophenone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Butein (CAS 487-52-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-12542-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.