Bosutinib

Also known as: SKI-606, Bosulif, 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, SKI 606, SK 606

Bosutinib (CAS 380843-75-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C26H29Cl2N5O3 and a molecular weight of 530.45600 g/mol. Key properties include a melting point of 116-120ºC, a boiling point of 649.7±55.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 346.7±31.5 °C. It is classified under GHS with signal word Warning and hazard statements H319 — Causes serious eye irritation and H413. No supplier offers are currently listed; request a quote. Record last updated Nov 4, 2026.

CAS No.: 380843-75-4
Jingsj CID: J-1138681-5
Molecular Formula: C₂₆H₂₉Cl₂N₅O₃
Molecular Weight: 530.45600 g/mol
Category: Organic Compounds
Last updated: 11/4/2026

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Physicochemical Properties

Melting Point	116-120ºC
Boiling Point	649.7±55.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	346.7±31.5 °C
Exact Mass	529.164734
PSA	82.88000
LogP	5.48
Vapor Pressure	0.0±1.9 mmHg at 25°C
Refractive Index	1.652
Storage Conditions	room temp

GHS Safety & Compliance

IrritantSignal word: Warning

H319 — Causes serious eye irritation
H413

Activity & Biological Data

Additional Information	[1]. Boschelli DH, et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem, 2001, 44(23), 3965-3977. [2]. Golas JM, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res, 2003, 63(2), 375-381. [3]. Vultur A, et al. SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther, 2008, 7(5), 1185-1194. [4]. Golas JM, et al. SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res, 2005, 65(12), 5358-5364.

Additional Information

[1]. Boschelli DH, et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem, 2001, 44(23), 3965-3977. [2]. Golas JM, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res, 2003, 63(2), 375-381. [3]. Vultur A, et al. SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther, 2008, 7(5), 1185-1194. [4]. Golas JM, et al. SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res, 2005, 65(12), 5358-5364.

Frequently Asked Questions

What is the CAS number of Bosutinib?

The CAS number of Bosutinib is 380843-75-4.

What are the molecular formula and molecular weight of Bosutinib?

Bosutinib has molecular formula C26H29Cl2N5O3 and molecular weight 530.45600 g/mol.

Is Bosutinib hazardous?

Bosutinib has GHS signal word Warning and hazard statements H319 — Causes serious eye irritation; H413.

What are the upstream and downstream products of Bosutinib?

For Bosutinib, Upstream Products: 1-Methylpiperazine, 7-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methoxyquinoline-3-carbonitrile, 1-(3-Hydroxypropyl)-4-methylpiperazine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/4/2026

How to cite: Jingsj. "Bosutinib (CAS 380843-75-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1138681-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.