5-Fluorouracil
Also known as: 5-FU, Fluorouracil, 5-Fluoropyrimidine-2,4(1H,3H)-dione, 2,4-Dihydroxy-5-fluoropyrimidine, 5-Fluoro-2,4(1H,3H)-pyrimidinedione, Adrucil, Efudex, Efudix, Carac, Fluoroplex, 5-Fluoropyrimidine-2,4-dione, 5-Fluoro-2,4-dioxopyrimidine, 2,4-Dioxo-5-fluoropyrimidine, FU
5-Fluorouracil (CAS 51-21-8) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C4H3FN2O2 and a molecular weight of 130.077 g/mol. Key properties include a melting point of 282-286 °C (dec.)(lit.), a boiling point of 401.4±48.0 °C at 760 mmHg, a density of 1.7±0.1 g/cm3 and a flash point of 196.5±29.6 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed and H412 — Harmful to aquatic life with long lasting effects. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 51-21-8
- Jingsj CID
- J-11383-6
- Molecular Formula
- C4H3FN2O2
- Molecular Weight
- 130.077 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 282-286 °C (dec.)(lit.) |
|---|---|
| Boiling Point | 401.4±48.0 °C at 760 mmHg |
| Density | 1.7±0.1 g/cm3 |
| Flash Point | 196.5±29.6 °C |
| Exact Mass | 130.017853 |
| PSA | 65.72000 |
| LogP | -2.10 |
| Vapor Pressure | 0.0±1.0 mmHg at 25°C |
| Refractive Index | 1.596 |
| Stability | Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases. |
| Additional Property | 12.2 g/L 20 ºC |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H412 — Harmful to aquatic life with long lasting effects
Activity & Biological Data
| Additional Information | [1]. Han R, et al. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy. J Drug Target. 2016 Jun 29:1-28. [Epub ahead of print] [2]. McQuade RM, et al. Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil. Neurogastroenterol Motil. 2016 Jun 28. [3]. Zeng Q, et al. Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells. Mol Cell Biochem. 2016 Jul;418(1-2):137-46. [4]. Yin L, et al. Antitumor effects of oncolytic herpes simplex virus type 2 against colorectal cancer in vitro and in vivo. Ther Clin Risk Manag. 2017 Feb 7;13:117-130. |
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Customs & Trade Information
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of 5-Fluorouracil?
The CAS number of 5-Fluorouracil is 51-21-8.
What are the molecular formula and molecular weight of 5-Fluorouracil?
5-Fluorouracil has molecular formula C4H3FN2O2 and molecular weight 130.077 g/mol.
Is 5-Fluorouracil hazardous?
5-Fluorouracil has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H412 — Harmful to aquatic life with long lasting effects.
What are the upstream and downstream products of 5-Fluorouracil?
For 5-Fluorouracil, Upstream Products: Cytosine, Uracil, Cytosine hydrochloride; Downstream Products: Uracil, Floxuridine, Thymine.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "5-Fluorouracil (CAS 51-21-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-11383-6 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.