Tris(hydroxymethyl)aminomethane hydrochloride

Also known as: 2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride, Trometamol hydrochloride, Tromethane hydrochloride, Trizma hydrochloride, TRIS hydrochloride, Tris-HCl, Tromethamine hydrochloride, Trimethylolaminomethane hydrochloride

Tris(hydroxymethyl)aminomethane hydrochloride (CAS 1185-53-1) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C4H12ClNO3 and a molecular weight of 157.596 g/mol. Key properties include a melting point of 150-152 °C, a boiling point of 357ºC at 760 mmHg, a density of 1.05 g/mL at 20 °C and a flash point of 169.7ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1185-53-1
Jingsj CID: J-1130529-6
Molecular Formula: C₄H₁₂ClNO₃
Molecular Weight: 157.596 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	150-152 °C
Boiling Point	357ºC at 760 mmHg
Density	1.05 g/mL at 20 °C
Flash Point	169.7ºC
Exact Mass	157.050568
PSA	86.71000
Additional Property	SOLUBLE

Activity & Biological Data

Additional Information	[1]. Nahas GG, et al. Guidelines for the treatment of acidaemia with THAM. Drugs. 1998 Feb;55(2):191-224.

Customs & Trade Information

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Tris(hydroxymethyl)aminomethane hydrochloride?

The CAS number of Tris(hydroxymethyl)aminomethane hydrochloride is 1185-53-1.

What are the molecular formula and molecular weight of Tris(hydroxymethyl)aminomethane hydrochloride?

Tris(hydroxymethyl)aminomethane hydrochloride has molecular formula C4H12ClNO3 and molecular weight 157.596 g/mol.

What are the upstream and downstream products of Tris(hydroxymethyl)aminomethane hydrochloride?

For Tris(hydroxymethyl)aminomethane hydrochloride, Downstream Products: Glycine hydrochloride, 2,2-Dimethyl-1,3-dioxan-5-one, (5-Amino-2,2-dimethyl-1,3-dioxan-5-yl)methanol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tris(hydroxymethyl)aminomethane hydrochloride (CAS 1185-53-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1130529-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.