CCT 137690

Also known as: CCT137690, CCT-137690, 3-[[4-[6-Bromo-2-[4-(4-methylpiperazin-1-yl)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]methyl]-5-methylisoxazole, 6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine, 6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridine, 3H-Imidazo[4,5-b]pyridine, 6-bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-

CCT 137690 (CAS 1095382-05-0) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C26H31BrN8O and a molecular weight of 551.481 g/mol. Key properties include a boiling point of 722.9±70.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 391.0±35.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1095382-05-0
Jingsj CID: J-1126735-9
Molecular Formula: C₂₆H₃₁BrN₈O
Molecular Weight: 551.481 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	722.9±70.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	391.0±35.7 °C
Exact Mass	550.180420
PSA	80.56000
LogP	3.07
Vapor Pressure	0.0±2.3 mmHg at 25°C
Refractive Index	1.664
Storage Conditions	-20℃

Activity & Biological Data

Target	Aurora A:15 nM (IC50) Aurora B:25 nM (IC50) Aurora C:19 nM (IC50)
Additional Information	[1]. Bavetsias V, et al. Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J Med Chem. 2010 Jul 22;53(14):5213-28. [2]. Faisal A, et al. The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol Cancer Ther. 2011 Nov;10(11):2115-23.

Target

Aurora A:15 nM (IC50) Aurora B:25 nM (IC50) Aurora C:19 nM (IC50)

Additional Information

[1]. Bavetsias V, et al. Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J Med Chem. 2010 Jul 22;53(14):5213-28. [2]. Faisal A, et al. The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol Cancer Ther. 2011 Nov;10(11):2115-23.

Frequently Asked Questions

What is the CAS number of CCT 137690?

The CAS number of CCT 137690 is 1095382-05-0.

What are the molecular formula and molecular weight of CCT 137690?

CCT 137690 has molecular formula C26H31BrN8O and molecular weight 551.481 g/mol.

What are the upstream and downstream products of CCT 137690?

For CCT 137690, Upstream Products: 4-(4-Methylpiperazin-1-yl)benzaldehyde.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "CCT 137690 (CAS 1095382-05-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1126735-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.