![Molecular structure of 8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide (CAS 1627676-59-8)](/images/chem_structures_svg/273/1627676-59-8.svg)
8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide
Also known as: PFI-2, (R)-PFI-2, PFI2, CS-1808, 6-Isoquinolinesulfonamide, 8-fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-, 8-Fluoro-N-[(2R)-1-oxo-1-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide (CAS 1627676-59-8) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C23H25F4N3O3S and a molecular weight of 499.522 g/mol. Key properties include a boiling point of 642.7±65.0 °C at 760 mmHg, a density of 1.371±0.06 g/cm3 and a flash point of 342.5±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 1627676-59-8
- Jingsj CID
- J-1113246-8
- Molecular Formula
- C23H25F4N3O3S
- Molecular Weight
- 499.522 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 642.7±65.0 °C at 760 mmHg |
|---|---|
| Density | 1.371±0.06 g/cm3 |
| Flash Point | 342.5±34.3 °C |
| Exact Mass | 499.155273 |
| PSA | 86.89000 |
| LogP | 3.55 |
| Vapor Pressure | 0.0±1.9 mmHg at 25°C |
| Refractive Index | 1.566 |
| Storage Conditions | 2-8℃ |
| Additional Property | Practically insoluble (0.06 g/L) (25 ºC) |
Activity & Biological Data
| Additional Information | [1]. Barsyte-Lovejoy D, et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8. |
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Frequently Asked Questions
What is the CAS number of 8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide?
The CAS number of 8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide is 1627676-59-8.
What are the molecular formula and molecular weight of 8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide?
8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide has molecular formula C23H25F4N3O3S and molecular weight 499.522 g/mol.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide (CAS 1627676-59-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1113246-8 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.