PF-431396

Also known as: PF431396, N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide, N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide, N-methyl-N-(2-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)phenyl)methanesulfonamide, PF-431396 hydrate, Methanesulfonamide, N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-

PF-431396 (CAS 717906-29-1) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C22H21F3N6O3S and a molecular weight of 506.501 g/mol. Key property: a density of 1.5±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 717906-29-1
Jingsj CID: J-1113229-9
Molecular Formula: C₂₂H₂₁F₃N₆O₃S
Molecular Weight: 506.501 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.5±0.1 g/cm3
Exact Mass	506.134796
PSA	127.93000
LogP	1.36
Appearance	off-white to blue-gray
Refractive Index	1.643
Storage Conditions	2-8°C
Additional Property	DMSO: ≥10mg/mL

Activity & Biological Data

Additional Information	[1]. Buckbinder L, et al. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10619-24. [2]. Ciceri P, et al. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat Chem Biol. 2014 Mar 2. [3]. Tse KW, et al. B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J Biol Chem. 2009 Aug 21;284(34):22865-77.

Additional Information

[1]. Buckbinder L, et al. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10619-24. [2]. Ciceri P, et al. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat Chem Biol. 2014 Mar 2. [3]. Tse KW, et al. B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J Biol Chem. 2009 Aug 21;284(34):22865-77.

Frequently Asked Questions

What is the CAS number of PF-431396?

The CAS number of PF-431396 is 717906-29-1.

What are the molecular formula and molecular weight of PF-431396?

PF-431396 has molecular formula C22H21F3N6O3S and molecular weight 506.501 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "PF-431396 (CAS 717906-29-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1113229-9 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.