2,2',4'-Trichloroacetophenone

Also known as: 2,2',4'-Trichloroacetophenone, 2,4-Dichlorophenacyl chloride, 2,4-dichlorophenyl chloromethyl ketone, Ethanone, 2-chloro-1-(2,4-dichlorophenyl)-, α,2,4-Trichloroacetophenone, ω,2,4-Trichloroacetophenone, 2-Chloro-1-(2,4-dichlorophenyl)ethanone, MFCD00000934, EINECS 224-218-2

2,2',4'-Trichloroacetophenone (CAS 4252-78-2) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C8H5Cl3O and a molecular weight of 223.484 g/mol. Key properties include a melting point of 47-54 °C(lit.), a boiling point of 292.2±25.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 122.1±23.7 °C. It is classified under GHS with signal word Danger and hazard statements H315 — Causes skin irritation, H317 — May cause an allergic skin reaction and H318 — Causes serious eye damage. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 4252-78-2
Jingsj CID: J-1100631-8
Molecular Formula: C₈H₅Cl₃O
Molecular Weight: 223.484 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	47-54 °C(lit.)
Boiling Point	292.2±25.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	122.1±23.7 °C
Exact Mass	221.940598
PSA	17.07000
LogP	2.97
Vapor Pressure	0.0±0.6 mmHg at 25°C
Refractive Index	1.565
Additional Property	60 mg/L (20 ºC)

GHS Safety & Compliance

Corrosion / IrritantSignal word: Danger

H315 — Causes skin irritation
H317 — May cause an allergic skin reaction
H318 — Causes serious eye damage
H335 — May cause respiratory irritation

Customs & Trade Information

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of 2,2',4'-Trichloroacetophenone?

The CAS number of 2,2',4'-Trichloroacetophenone is 4252-78-2.

What are the molecular formula and molecular weight of 2,2',4'-Trichloroacetophenone?

2,2',4'-Trichloroacetophenone has molecular formula C8H5Cl3O and molecular weight 223.484 g/mol.

Is 2,2',4'-Trichloroacetophenone hazardous?

2,2',4'-Trichloroacetophenone has GHS signal word Danger and hazard statements H315 — Causes skin irritation; H317 — May cause an allergic skin reaction; H318 — Causes serious eye damage.

What are the upstream and downstream products of 2,2',4'-Trichloroacetophenone?

For 2,2',4'-Trichloroacetophenone, Upstream Products: 2',4'-Dichloroacetophenone, Chloroacetyl chloride, 1,3-Dichlorobenzene; Downstream Products: 2,4-Dichlorobenzoic acid, 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone, 2',4'-Dichloro-2-imidazole acetophenone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2,2',4'-Trichloroacetophenone (CAS 4252-78-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1100631-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.