24(S)-Hydroxycholesterol

Also known as: (3β,24S)-Cholest-5-ene-3,24-diol, Cholest-5-ene-3β,24(S)-diol, Cerebrosterol, 24S-Hydroxycholesterol, 24S-OHC

24(S)-Hydroxycholesterol (CAS 474-73-7) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C27H46O2 and a molecular weight of 402.653 g/mol. Key properties include a melting point of 174-176°C (lit.), a boiling point of 513.1±23.0 °C at 760 mmHg, a density of 1.0±0.1 g/cm3 and a flash point of 213.5±17.2 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 474-73-7
Jingsj CID: J-1079059-7
Molecular Formula: C₂₇H₄₆O₂
Molecular Weight: 402.653 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	174-176°C (lit.)
Boiling Point	513.1±23.0 °C at 760 mmHg
Density	1.0±0.1 g/cm3
Flash Point	213.5±17.2 °C
Exact Mass	402.349792
PSA	40.46000
LogP	7.66
Vapor Pressure	0.0±3.0 mmHg at 25°C
Refractive Index	1.536
Storage Conditions	20°C

Activity & Biological Data

Target	Human Endogenous Metabolite
Additional Information	[1]. Yuki Kimura, et al. Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie. 2018 Oct;153:203-209. [2]. M Shafaati, et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 2011 Oct;270(4):377-87. [3]. Steven M Paul, et al. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33(44):17290-300.

Target

Human Endogenous Metabolite

Additional Information

[1]. Yuki Kimura, et al. Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie. 2018 Oct;153:203-209. [2]. M Shafaati, et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 2011 Oct;270(4):377-87. [3]. Steven M Paul, et al. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33(44):17290-300.

Frequently Asked Questions

What is the CAS number of 24(S)-Hydroxycholesterol?

The CAS number of 24(S)-Hydroxycholesterol is 474-73-7.

What are the molecular formula and molecular weight of 24(S)-Hydroxycholesterol?

24(S)-Hydroxycholesterol has molecular formula C27H46O2 and molecular weight 402.653 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "24(S)-Hydroxycholesterol (CAS 474-73-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1079059-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.