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N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea

Also known as: Rebastinib, DCC-2036, DCC2036, DP-1919, 1-(3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea, 4-[4-({[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, 2-Pyridinecarboxamide, 4-[4-[[[[3-(1,1-dimethylethyl)-1-(6-quinolinyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-

N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea (CAS 1020172-07-9) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C30H28FN7O3 and a molecular weight of 553.587 g/mol. Key properties include a boiling point of 666.8±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 357.0±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
1020172-07-9
Jingsj CID
J-1072819-5
Molecular Formula
C30H28FN7O3
Molecular Weight
553.587 g/mol
Category
Pharma Intermediates
Last updated
8/21/2026
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Physicochemical Properties

Boiling Point666.8±55.0 °C at 760 mmHg
Density1.3±0.1 g/cm3
Flash Point357.0±31.5 °C
Exact Mass553.223755
PSA126.55000
LogP4.90
Vapor Pressure0.0±2.0 mmHg at 25°C
Refractive Index1.655
Storage Conditions-20℃

Activity & Biological Data

TargetIC50: 0.75±0.11 nM (ABL1WT), 2±0.3 nM (FLT3), 4±0.3 nM (KDR), 6±0.3 nM (TIE2), 34±6 nM (SRC)[1]
Additional Information[1]. Chan WW, et al. Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell. 2011, 19(4), 556-568.

Frequently Asked Questions

What is the CAS number of N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea?

The CAS number of N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea is 1020172-07-9.

What are the molecular formula and molecular weight of N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea?

N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea has molecular formula C30H28FN7O3 and molecular weight 553.587 g/mol.

What are the upstream and downstream products of N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea?

For N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea, Upstream Products: 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide, 6-Hydroxyquinoline, 6-quinolinyl trifluoromethanesulfonate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea (CAS 1020172-07-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1072819-5 (accessed 2026-11-09).

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