LY2874455
Also known as: LY-2874455, LY 2874455, 4-[(1E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol, (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol, (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethan-1-ol, 2-{4-[(E)-2-{5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl}vinyl]-1H-pyrazol-1-yl}ethanol, CS-0907, QCR-90
LY2874455 (CAS 1254473-64-7) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C21H19Cl2N5O2 and a molecular weight of 444.314 g/mol. Key properties include a boiling point of 672.6±55.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 360.5±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 1254473-64-7
- Jingsj CID
- J-1047924-0
- Molecular Formula
- C21H19Cl2N5O2
- Molecular Weight
- 444.314 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 672.6±55.0 °C at 760 mmHg |
|---|---|
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 360.5±31.5 °C |
| Exact Mass | 443.091583 |
| PSA | 88.85000 |
| LogP | 3.88 |
| Vapor Pressure | 0.0±2.2 mmHg at 25°C |
| Refractive Index | 1.683 |
Activity & Biological Data
| Target | FGFR1:2.8 nM (IC50) FGFR2:2.6 nM (IC50) FGFR3:6.4 nM (IC50) FGFR4:6 nM (IC50) |
|---|---|
| Additional Information | [1]. Zhao G, et al. A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows a Potent Broad Spectrum of Antitumor Activity in Several Tumor Xenograft Models. Molecular Cancer Therapeutics (2011), 10(11), 2200-2210. |
Frequently Asked Questions
What is the CAS number of LY2874455?
The CAS number of LY2874455 is 1254473-64-7.
What are the molecular formula and molecular weight of LY2874455?
LY2874455 has molecular formula C21H19Cl2N5O2 and molecular weight 444.314 g/mol.
What are the upstream and downstream products of LY2874455?
For LY2874455, Upstream Products: 1H-Indazol-5-ol, 4-iodo-1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole, 3,5-Dichloropyridine.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "LY2874455 (CAS 1254473-64-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1047924-0 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.