Methotrexate
Also known as: Amethopterin, MTX, 4-Amino-10-methylfolic acid, 4-Amino-N10-methylpteroylglutamic acid, L-Amethopterin, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid, (+)-Amethopterin, 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic acid, L-(+)-N-[p-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]glutamic Acid, Mexate
Methotrexate (CAS 59-05-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H22N8O5 and a molecular weight of 454.439 g/mol. Key properties include a melting point of 195°C, a boiling point of 561.26°C, a density of 1.4080 and a flash point of 11℃. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 59-05-2
- Jingsj CID
- J-1014813-7
- Molecular Formula
- C20H22N8O5
- Molecular Weight
- 454.439 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 195°C |
|---|---|
| Boiling Point | 561.26°C |
| Density | 1.4080 |
| Flash Point | 11℃ |
| Exact Mass | 454.171326 |
| PSA | 210.54000 |
| LogP | -0.24 |
| Refractive Index | 1.6910 |
| Stability | Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below. |
| Additional Property | Insoluble. <0.1 g/100 mL at 19 ºC |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H340
- H360 — May damage fertility or the unborn child
Activity & Biological Data
| Target | Antifolate[1] |
|---|---|
| Additional Information | [1]. Norris RE, et al. Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias. Cancer Chemother Pharmacol. 2010 May;65(6):1125-30. [2]. Gu S, et al. Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals. PeerJ. 2016 May 11;4:e1983. |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Methotrexate?
The CAS number of Methotrexate is 59-05-2.
What are the molecular formula and molecular weight of Methotrexate?
Methotrexate has molecular formula C20H22N8O5 and molecular weight 454.439 g/mol.
Is Methotrexate hazardous?
Methotrexate has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Methotrexate (CAS 59-05-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1014813-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.