Rauwolscine hydrochloride

Also known as: α-Yohimbine hydrochloride, Isoyohimbine hydrochloride, Corynanthidine hydrochloride, Rauwolscine HCl, Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, hydrochloride (1:1), (16β,17α,20α)-, 20α-Yohimban-16β-carboxylic acid, 17α-hydroxy-, methyl ester, monohydrochloride, NSC 407307, Mesoyohimbine, Rauwolfscine hydrochloride

Rauwolscine hydrochloride (CAS 6211-32-1) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C21H27ClN2O3 and a molecular weight of 390.904 g/mol. Key properties include a melting point of 270-280ºC, a boiling point of 543ºC at 760 mmHg, a density of 1.31 g/cm3 and a flash point of 282.2ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 6211-32-1
Jingsj CID: J-10032-6
Molecular Formula: C₂₁H₂₇ClN₂O₃
Molecular Weight: 390.904 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	270-280ºC
Boiling Point	543ºC at 760 mmHg
Density	1.31 g/cm3
Flash Point	282.2ºC
Exact Mass	390.171021
PSA	65.56000
LogP	3.38700
Additional Property	H2O: soluble

Activity & Biological Data

Target	Ki: 12 nM (α2 adrenergic receptor)[1]
Additional Information	[1]. Perry BD, et al. [3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol. 1981 Dec 17;76(4):461-4. [2]. De Vos H, et al. [3H]rauwolscine behaves as an agonist for the 5-HT1A receptors in human frontal cortex membranes. Eur J Pharmacol. 1991 May 25;207(1):1-8. [3]. Wainscott DB, et al. [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):17-24. [4]. Neylon CB, et al. [3H]-rauwolscine binding to alpha 2-adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species. Br J Pharmacol. 1985 Jun;85(2):349-59.

Target

Ki: 12 nM (α2 adrenergic receptor)[1]

Additional Information

[1]. Perry BD, et al. [3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol. 1981 Dec 17;76(4):461-4. [2]. De Vos H, et al. [3H]rauwolscine behaves as an agonist for the 5-HT1A receptors in human frontal cortex membranes. Eur J Pharmacol. 1991 May 25;207(1):1-8. [3]. Wainscott DB, et al. [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):17-24. [4]. Neylon CB, et al. [3H]-rauwolscine binding to alpha 2-adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species. Br J Pharmacol. 1985 Jun;85(2):349-59.

Frequently Asked Questions

What is the CAS number of Rauwolscine hydrochloride?

The CAS number of Rauwolscine hydrochloride is 6211-32-1.

What are the molecular formula and molecular weight of Rauwolscine hydrochloride?

Rauwolscine hydrochloride has molecular formula C21H27ClN2O3 and molecular weight 390.904 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Rauwolscine hydrochloride (CAS 6211-32-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-10032-6 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.