[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-9651-1":171,"verified-suppliers-J-9651-1":382},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":193,"ghs":249,"offers":259,"activity":260,"upstream":276,"downstream":301,"customs":314,"safetyRows":315,"toxicity":339,"synthesis":340,"updatedAt":341,"isProhibited":342,"related":343,"__ts":380,"__lang":381,"__slug":173},"785883837086306304","J-9651-1","\u002Fimages\u002Fchem_structures_svg\u002F448\u002F50-52-2.svg","硫利达嗪","50-52-2","C21H26N2S2","370.574","organic","有机化合物","Organic Compounds",[],[184,185,186,187,188,189,190,191,192],"甲硫哒嗪","甲硫哌啶","甲硫达嗪","硫利哒嗪","硫醚嗪","硫利达嗪(甲硫哒嗪)","利达新","美立廉","眠立乐",[194,198,202,206,210,214,217,220,223,227,231,235,238,242,246],{"label":195,"labelZh":195,"value":196,"prop":197},"Melting Point","72-74°","meltingPoint",{"label":199,"labelZh":199,"value":200,"prop":201},"Boiling Point","515.7±50.0 °C at 760 mmHg","boilingPoint",{"label":203,"labelZh":203,"value":204,"prop":205},"Density","1.2±0.1 g\u002Fcm3","density",{"label":207,"labelZh":207,"value":208,"prop":209},"Flash Point","265.7±30.1 °C","flashPoint",{"label":211,"labelZh":212,"value":213},"Exact Mass","精确质量","370.153748",{"label":215,"labelZh":215,"value":216},"PSA","57.08000",{"label":218,"labelZh":218,"value":219},"LogP","6.13",{"label":221,"labelZh":221,"value":222},"外观性状","液体",{"label":224,"labelZh":225,"value":226},"Vapor Pressure","蒸汽压","0.0±1.3 mmHg at 25°C",{"label":228,"labelZh":229,"value":230},"Refractive Index","折射率","1.677",{"label":232,"labelZh":233,"value":234},"Storage Conditions","储存条件","本品密封避光干燥保存。",{"label":236,"labelZh":236,"value":237},"水溶解性","Practically insoluble in water, very soluble in methylene chloride, freely soluble in methanol, soluble in ethanol (96 per cent).",{"label":239,"labelZh":240,"value":241},"Molecular Structure","分子结构","1、 摩尔折射率：112.80\n2、 摩尔体积（cm\n3\n\u002Fmol）：299.5\n3、 等张比容（90.2K）：829.1\n4、 表面张力（dyne\u002Fcm）：58.6\n5、 极化率（10-24cm3）：44.71",{"label":243,"labelZh":244,"value":245},"Computational Chemistry","计算化学","1.疏水参数计算参考值（XlogP）:无\n2.氢键供体数量:0\n3.氢键受体数量:4\n4.可旋转化学键数量:4\n5.互变异构体数量:无\n6.拓扑分子极性表面积57.1\n7.重原子数量:25\n8.表面电荷:0\n9.复杂度:432\n10.同位素原子数量:0\n11.确定原子立构中心数量:0\n12.不确定原子立构中心数量:1\n13.确定化学键立构中心数量:0\n14.不确定化学键立构中心数量:0\n15.共价键单元数量:1",{"label":247,"labelZh":247,"value":248},"更多","1. 性状： 晶体。\n2. 密度（g\u002FmL,25\u002F4℃）：未确定\n3. 相对蒸汽密度（g\u002FmL,空气=1）：未确定\n4. 熔点（ºC）：72～74℃\n5. 沸点（ºC,常压）：未确定\n6. 沸点（ºC, 5.2 kPa）：未确定\n7. 折射率：未确定\n8. 闪点（ºC）：未确定\n9. 比旋光度（º）：未确定\n10. 自燃点或引燃温度（ºC）：未确定\n11. 蒸气压（kPa,25 ºC）：未确定\n12. 饱和蒸气压（kPa,60 ºC）：未确定\n13. 燃烧热（KJ\u002Fmol）：未确定\n14. 临界温度（ºC）：未确定\n15. 临界压力（KPa）：未确定\n16. 油水（辛醇\u002F水）分配系数的对数值：未确定\n17. 爆炸上限（%,V\u002FV）：未确定\n18. 爆炸下限（%,V\u002FV）：未确定\n19. 溶解性：未确定",{"pictogram":250,"signal":251,"hazards":252},"Flammable \u002F Acute Toxicity \u002F Health Hazard","Danger",[253,254,255,256,257,258],"H225 — Highly flammable liquid and vapour \u002F 高度易燃液体和蒸气","H301 — Toxic if swallowed \u002F 吞咽会中毒","H311 — Toxic in contact with skin \u002F 皮肤接触会中毒","H331 — Toxic if inhaled \u002F 吸入会中毒","H370 — Causes damage to organs \u002F 对器官造成损害","H412 — Harmful to aquatic life with long lasting effects \u002F 对水生生物有害并具有长期持续影响",[],[261,264,267,270,273],{"key":262,"value":263},"描述","硫利达嗪是多巴胺受体D2家族蛋白的拮抗剂,具有强大的抗精神病和抗焦虑活性。硫利达嗪也是PI3K-Akt-mTOR信号通路的有效抑制剂,具有抗血管生成作用。硫利达嗪在各种类型的癌细胞中显示出抗增殖和诱导凋亡作用,对靶向癌干细胞(CSCs)具有特异性[1][2][3][4]。",{"key":265,"value":266},"相关类别","信号通路\n>>\n细胞凋亡\n>>\n细胞凋亡\n信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n多巴胺受体\n信号通路\n>>\n神经信号通路\n>>\n多巴胺受体\n研究领域\n>>\n神经疾病\n信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n5-HT受体\n信号通路\n>>\n神经信号通路\n>>\n5-HT受体\n信号通路\n>>\n抗感染\n>>\n细菌",{"key":268,"value":269},"体外研究","硫利达嗪(0.01-100μM；48小时)以浓度依赖性方式降低NCI-N87和AGS细胞的细胞活力[2]。硫利达嗪(15μM；24小时)降低宫颈癌细胞(HeLa、Caski和C33A)和子宫内膜癌细胞(HEC-1-A和KLE)的细胞活力[4]。硫利达嗪(1-15μM；24-48小时)通过线粒体凋亡途径和线粒体途径诱导胃癌细胞死亡[2]。硫利达嗪(15μM；24 h)通过干扰PI3K\u002FAkt通路调节细胞周期进程,并诱导宫颈癌和子宫内膜癌细胞G1细胞周期阻滞[4]。硫利达嗪抑制鲍曼不动杆菌对抗生素敏感和多重耐药菌株的生长[3]。细胞活力测定[1]细胞系：NCI-N87和AGS细胞。浓度：0.01,0.1,0.5,1,5,10,20,50,100μM。培养时间：48小时。结果：对胃癌细胞具有细胞毒性。Western Blot分析[1]细胞系：NCI-N87和AGS细胞浓度：1,5,10,15μM。培养时间：24,48小时。结果：caspase-9、caspase-8和caspase-3的前体表达下调。",{"key":271,"value":272},"体内研究","硫利达嗪(25mg\u002Fkg；连续3周每3天注射一次)可延长荷瘤小鼠的存活时间,并减少肿瘤内多能性胚胎癌(EC)细胞的数量[5]。硫利达嗪(1.0-5.0 mg\u002Fkg；s.c.)可减少口腔行为,并选择性地阻止重复的头部摆动[1]。动物模型：裸鼠和Rag2KO小鼠注射iPS细胞或NT2D1细胞[5]剂量：25mg\u002Fkg。给药：每3天注射一次,持续3周。结果：减少了恶性畸胎瘤中OCT4表达细胞的数量,延长了荷瘤小鼠的生存期。对生育率没有影响。",{"key":274,"value":275},"参考文献","[1].\nTschanz JT, et, al. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol Biochem Behav. 1988 Nov;31(3):519-22.\n[2].\nMu J, et, al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. Oncol Rep. 2014 May;31(5):2107-14.\n[3].\nKang S, et, al. Thioridazine induces apoptosis by targeting the PI3K\u002FAkt\u002FmTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep;17(9):989-97.\n[4].\nLoehr AR, et, al. Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. Cancers (Basel). 2021 Apr 23;13(9):2045.",[277,283,289,295],{"slug":278,"cid":279,"name":280,"nameZh":280,"cas":281,"imgSvg":282},"785889184203149300","J-1384352-6","2-甲硫基吩噻嗪","7643-08-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F455\u002F7643-08-5.svg",{"slug":284,"cid":285,"name":286,"nameZh":286,"cas":287,"imgSvg":288},"785892912859713500","J-1494142-5","3-甲硫基-N-苯基苯胺","13313-45-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F184\u002F13313-45-6.svg",{"slug":290,"cid":291,"name":292,"nameZh":292,"cas":293,"imgSvg":294},"785872820239339500","J-1344201-5","3-氨基茴香硫醚","1783-81-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F213\u002F1783-81-9.svg",{"slug":296,"cid":297,"name":298,"nameZh":298,"cas":299,"imgSvg":300},"785884625342828500","J-1319283-7","邻氯苯甲酸钾","16463-38-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F325\u002F16463-38-0.svg",[302,308],{"slug":303,"cid":304,"name":305,"nameZh":305,"cas":306,"imgSvg":307},"785875660949164000","J-1971905-2","美索哒嗪","5588-33-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F292\u002F5588-33-0.svg",{"slug":309,"cid":310,"name":311,"nameZh":311,"cas":312,"imgSvg":313},"785882191757316100","J-1312195-2","磺达嗪","14759-06-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F103\u002F14759-06-9.svg",[],[316,319,321,324,327,330,333,336],{"key":317,"value":318},"符号","GHS02, GHS06, GHS08",{"key":320,"value":251},"信号词",{"key":322,"value":323},"危害声明","H225-H301 + H311 + H331-H370-H412",{"key":325,"value":326},"警示性声明","P210-P260-P273-P280-P301 + P310-P311",{"key":328,"value":329},"危害码 (欧洲)","F,T",{"key":331,"value":332},"风险声明 (欧洲)","11-23\u002F24\u002F25-39\u002F23\u002F24\u002F25-52\u002F53",{"key":334,"value":335},"安全声明 (欧洲)","16-36\u002F37-45-61",{"key":337,"value":338},"危险品运输编码","UN1230 - class 3 - PG 2 - Methanol, solution","\u003Ctd>\n\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F50-52-2_511924.html#duXinDiv\">硫利达嗪毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Cp> 本品由丙酮中得晶体 \u003C\u002Fp>","2026-08-21T07:51:12.859463Z",false,[344,350,356,362,368,374],{"slug":345,"cid":346,"name":347,"nameZh":348,"cas":349},"785894536923582464","J-37904-3","Cinnarizine","桂利嗪","298-57-7",{"slug":351,"cid":352,"name":353,"nameZh":354,"cas":355},"785881392557854720","J-19181-0","Curcumin","姜黄素","458-37-7",{"slug":357,"cid":358,"name":359,"nameZh":360,"cas":361},"785896553968570368","J-1516137-4","Solvent Brown 53","溶剂棕53","64696-98-6",{"slug":363,"cid":364,"name":365,"nameZh":366,"cas":367},"785892567169372160","J-1114822-9","Methylene Blue trihydrate","亚甲基蓝三水合物","7220-79-3",{"slug":369,"cid":370,"name":371,"nameZh":372,"cas":373},"785872950262763520","J-1319798-8","EDTA ferric sodium salt","EDTA铁-钠盐","18154-32-0",{"slug":375,"cid":376,"name":377,"nameZh":378,"cas":379},"785880742256185344","J-1111861-9","Malachite green","孔雀石绿","569-64-2",1792638423401,"zh-CN",[]]