[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-90108-8":171,"verified-suppliers-J-90108-8":320},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":194,"ghs":220,"offers":221,"activity":222,"upstream":247,"downstream":260,"customs":261,"safetyRows":274,"updatedAt":279,"isProhibited":280,"related":281,"__ts":318,"__lang":319,"__slug":173},"785897377851510784","J-90108-8","\u002Fimages\u002Fchem_structures_svg\u002F155\u002F1316214-52-4.svg","空字符串","1316214-52-4","C24H27N5O3","433.503","organic","有机化合物","Organic Compounds",[],[184,185,186,187,188,189,190,191,192,193],"2-(二苯基氨基)-N-(7-(羟基氨基)-7-氧代庚基)嘧啶-5-甲酰胺","2-(二苯基氨基)-N-[7-(羟基氨基)-7-氧代庚基]-5-嘧啶甲酰胺","2-(二苯基氨基)-N-[7-(羟基氨基)-7-氧代庚基]-5-嘧啶羧酰胺","2-(二苯基氨基)-n-[7-(羟基氨基)-7-氧代庚基]-5-嘧啶羧酰胺","ACY1215","HDAC6抑制剂(ACY-1215)","Ricolinostat抑制剂","化合物:Rocilinostat (ACY-1215)","化合物ROCILINOSTAT","化合物ROCILINOSTAT,10 MM DMSO 溶液",[195,199,203,206,209,213,217],{"label":196,"labelZh":196,"value":197,"prop":198},"Density","1.2±0.1 g\u002Fcm3","density",{"label":200,"labelZh":201,"value":202},"Exact Mass","精确质量","433.211395",{"label":204,"labelZh":204,"value":205},"PSA","114.43000",{"label":207,"labelZh":207,"value":208},"LogP","1.41",{"label":210,"labelZh":211,"value":212},"Refractive Index","折射率","1.620",{"label":214,"labelZh":215,"value":216},"Storage Conditions","储存条件","室温，干燥，密封",{"label":218,"labelZh":218,"value":219},"水溶解性","Insuluble (4.3E-3 g\u002FL) (25 ºC)",null,[],[223,226,229,232,235,238,241,244],{"key":224,"value":225},"描述","Ricolinostat (ACY-1215) 是一种有效,选择性的 HDAC6 抑制剂,IC50 为 5 nM。ACY-1215 也可抑制 HDAC1,HDAC2 和 HDAC3,IC50 分别为 58,48 和 51 nM。",{"key":227,"value":228},"相关类别","信号通路\n>>\n细胞周期\u002FDNA损伤\n>>\nHDAC\n信号通路\n>>\n表观遗传学\n>>\nHDAC\n研究领域\n>>\n癌症",{"key":230,"value":231},"靶点","HDAC6:4.7 nM (IC50)\nHDAC2:48 nM (IC50)\nHDAC3:51 nM (IC50)\nHDAC1:58 nM (IC50)\nHDAC8:100 nM (IC50)\nHDAC7:1400 nM (IC50)\nHDAC5:5000 nM (IC50)\nHDAC4:7000 nM (IC50)",{"key":233,"value":234},"体外研究","Ricolinostat(ACY-1215)对HDAC8具有轻微活性(IC50 =0.1μM),对HDAC4,HDAC5,HDAC7,HDAC9,HDAC11,Sirtuin1和Sirtuin2的活性(IC50>1μM)最小。使用MM细胞系的MTT测定法测定Ricolinostat(ACY-1215)对多发性骨髓瘤(MM)细胞活力的影响。 MM细胞系暴露48小时导致剂量依赖性降低的活力,IC 50值范围为2-8μM。 Ricolinostat(ACY-1215)在MM Bortezomib抗性细胞系(ANBL-6BR)中显示出显着活性,证明了Ricolinostat(ACY-1215)克服硼替佐米抗性的能力[1]。",{"key":236,"value":237},"体内研究","用Ricolinostat(ACY-1215),硼替佐米或Ricolinostat加Bortezomib治疗的小鼠显示出肿瘤生长的显着延迟(分别为P = 0.01,P = 0.006和P \u003C0.0001)。与对照组(对照组17天,联合治疗组40天,P \u003C0.0001)和Ricolinostat(ACY)相比,与Ricolinostat和Bortezomib联合治疗显示肿瘤生长显着抑制并显着延长总生存期(OS) -1215)-治疗组(Bortezomib组22天,联合治疗组40天,P \u003C0.0001)。与治疗期间的当天对照组相比,联合治疗组的体重减轻在4％至12％之间,在最后一次注射后完全恢复。正如在浆细胞瘤模型中观察到的,通过将Ricolinostat与硼替佐米组合与单独的任一种药物相比,发现了显着的治疗优势[1]。",{"key":239,"value":240},"细胞实验","通过测量MTT染料吸光度来评估具有或不具有硼替佐米的Ricolinostat对MM细胞系，患者MM细胞和PBMC的生存力的影响。分离来自健康供体的PBMC，并在浓度增加的Ricolinostat（ACY-1215）存在下用2.5μg\u002F mL植物血凝素（PHA）刺激48小时。通过氚标记的胸苷摄取来测量DNA合成。使用Rosette Sep阴性选择试剂盒从人血液中纯化CD4 + T细胞。在化合物存在下，CD3 \u002F CD28 Dynabeads刺激细胞7天。使用alamarBlue评估细胞活力。将MM细胞（2-3×104细胞\u002F孔）在具有中等和不同浓度的Ricolinostat（ACY-1215），Bortezomib和\u002F或重组IL-6（10ng \u002F mL）或胰岛素的96孔培养板中孵育。样生长因子-1（IGF-1; 50ng \u002F mL）在37℃下24小时，并测量氚标记的胸苷掺入[1]。",{"key":242,"value":243},"动物实验","小鼠[1]为了评估Ricolinostat的体内抗MM活性，在100μL无血清RPMI 1640培养基中用5×106MM.1S细胞皮下接种雄性SCID小鼠。当肿瘤可测量时，小鼠用Ricolinostat 50mg \u002F kg IP溶于10％DMSO的5％葡萄糖水溶液中连续处理5天，持续3周;硼替佐米0.5mg \u002F kg每两周一次（IV）溶解于0.9％盐水溶液中连续3周;或与用于个体药剂的相同给药方案组合。对照组仅以与组合组相同的时间表接收承运人。使用卡尺每隔一天在2个维度上测量肿瘤大小，并且用以下公式计算肿瘤体积：V = 0.5（a×b2）其中a是肿瘤的长直径，b是肿瘤的短直径。当肿瘤达到2cm 3或溃疡时，小鼠被杀死。从治疗的第一天到死亡评估存活和肿瘤生长。",{"key":245,"value":246},"参考文献","[1].\nSanto L, et al. Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma. Blood. 2012 Mar 15;119(11):2579-89.",[248,254],{"slug":249,"cid":250,"name":251,"nameZh":251,"cas":252,"imgSvg":253},"785896945024503800","J-45835-5","2-氯嘧啶-5-羧酸乙酯","89793-12-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F105\u002F89793-12-4.svg",{"slug":255,"cid":256,"name":257,"nameZh":257,"cas":258,"imgSvg":259},"785895154266411000","J-1507596-3","2-羟基嘧啶-5-羧酸乙酯","95928-49-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F417\u002F95928-49-7.svg",[],[262,265,268,271],{"key":263,"value":264},"海关编码","2933599090",{"key":266,"value":267},"中文概述","2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":269,"value":270},"申报要素","品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期",{"key":272,"value":273},"Summary","2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[275,278],{"key":276,"value":277},"危害码 (欧洲)","Xi",{"key":263,"value":264},"2026-08-21T07:51:12.859463Z",false,[282,288,294,300,306,312],{"slug":283,"cid":284,"name":285,"nameZh":286,"cas":287},"785898367673700352","J-1988074-7","Pantoprazole Sodium Sesquihydrate","泮托拉唑钠倍半水合物","164579-32-2",{"slug":289,"cid":290,"name":291,"nameZh":292,"cas":293},"785875705589141504","J-10742-4","Neocuproine hemihydrate","新亚铜试剂半水合物","34302-69-7",{"slug":295,"cid":296,"name":297,"nameZh":298,"cas":299},"785882335940710400","J-3147-5","Pigment Red 57:1","颜料红57:1","5281-04-9",{"slug":301,"cid":302,"name":303,"nameZh":304,"cas":305},"785889757879078912","J-1372965-3","Calcium Saccharin Hydrate","糖精钙水合物","6381-91-5",{"slug":307,"cid":308,"name":309,"nameZh":310,"cas":311},"785881577656684544","J-1111912-6","Mordant Black 17","铬蓝黑R","2538-85-4",{"slug":313,"cid":314,"name":315,"nameZh":316,"cas":317},"785881331014832128","J-18850-2","Diosgenin","薯蓣皂苷元","512-04-9",1792626494617,"zh-CN",[]]