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Toxic if swallowed \u002F 吞咽会中毒",[],[260,263,266,269,272,275],{"key":261,"value":262},"描述","Brefeldin A是蛋白质运输 (protein trafficking) 的特异性抑制剂,其阻断蛋白质从内质网向高尔基复合体的转运。",{"key":264,"value":265},"相关类别","信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\n细胞周期\u002FDNA损伤\n>>\nCRISPR\u002FCas9\n信号通路\n>>\n自噬\n>>\n自噬\n天然产物\n>>\n其他\n研究领域\n>>\n癌症",{"key":267,"value":268},"靶点","CRISPR\u002FCas9",{"key":270,"value":271},"体外研究","布雷菲德菌素A治疗15小时或40小时,引起内质网(ER)的显着肿胀并将其定位转移至正常大鼠肾(NRK)细胞的外周。延长的布雷菲德菌素A治疗导致MT和肌动蛋白细胞骨架的显着破坏[1]。 BARS的ADP-核糖基化通过在布雷菲德菌素A和ADPR之间形成缀合物来介导。当与来自BFA处理的CD38 + HeLa细胞的培养基一起孵育时,BARS显示BAC结合[2]。 Brefeldin A在MDA-MB-231乳腺癌细胞中诱导不依赖贴壁的细胞死亡,抑制3D和2D培养物中MDA-MB-231集落的形成,并抑制MDA-MB的迁移和MMP 9(Matrix Metallopeptidase 9)活性-231 [3]。",{"key":273,"value":274},"细胞实验","将细胞在玻璃盖玻片上生长，在PBS中的3％多聚甲醛中固定（在室温下10分钟），然后在PBS中洗涤。在室温下用PBS中的0.01％Triton X-100透化细胞7分钟。将盖玻片洗涤（在PBS \u002F 0.2％吐温中3次），在PBS \u002F O.4％鱼皮明胶\u002F0.2%吐温（5分钟）和PBS \u002F 2.5％山羊血清\u002F0.2%吐温（5分钟）中孵育。 。封闭后，将细胞与一抗在37℃温育45分钟，然后用PBS \u002F 0.2％吐温洗涤（5次，每次5分钟）。在37℃下加入第二抗体30分钟，然后如上洗涤细胞。将盖玻片以9：1甘油\u002F PBS与0.1％邻苯二胺的载玻片安装在载玻片上。",{"key":276,"value":277},"参考文献","[1].\nAlvarez C, et al. Brefeldin A (BFA) disrupts the organization of the microtubule and the actin cytoskeletons. Eur J Cell Biol. 1999 Jan;78(1):1-14.\n[2].\nColanzi A, et al. Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1\u002FBARS. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9794-9.\n[3].\nTseng CN, et al. Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells. Molecules. 2014 Oct 29;19(11):17464-77.\n[4].\nWang J, et al. Erythroleukemia cells acquire an alternative mitophagy capability. Sci Rep. 2016 Apr 19;6:24641.\n[5].\nYu C, et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. 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