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Inhibitory effects of Vesnarinone on cloned cardiac delayed rectifier K(+) channels expressed in a mammalian cell line. J Pharmacol Exp Ther. 2000 Jul;294(1):339-46.\n[2].\nInage M, et al. Vesnarinone represses the fibrotic changes in murine lung injury induced by bleomycin. Int J Biol Sci. 2009;5(4):304-10.\n[3].\nCavusoglu E, et al. Vesnarinone: a new inotropic agent for treating congestive heart failure. J Card Fail. 1995 Jun;1(3):249-57.\n[4].\nMatsumori A, et al. Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure. Circulation. 1994 Mar;89(3):955-8.",[252,258,264],{"slug":253,"cid":254,"name":255,"nameZh":255,"cas":256,"imgSvg":257},"785895691720331300","J-1511049-1","6-氨基-3,4-二氢-2(1...","22246-13-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F211\u002F22246-13-5.svg",{"slug":259,"cid":260,"name":261,"nameZh":261,"cas":262,"imgSvg":263},"785896971708665900","J-45955-8","3,4-二甲氧基苯甲酰氯","3535-37-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F207\u002F3535-37-3.svg",{"slug":265,"cid":266,"name":267,"nameZh":267,"cas":268,"imgSvg":269},"785893938648059900","J-1499706-6","双(2-溴乙基)胺氢溴酸盐","43204-63-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F461\u002F43204-63-3.svg",[271,277],{"slug":272,"cid":273,"name":274,"nameZh":274,"cas":275,"imgSvg":276},"785891823926120400","J-31220-8","3,4-二甲氧基苯甲酸乙酯","3943-77-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F004\u002F3943-77-9.svg",{"slug":278,"cid":279,"name":280,"nameZh":280,"cas":281,"imgSvg":282},"785897816030449700","J-48026-0","藜芦酸","93-07-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F179\u002F93-07-2.svg",[],[],"\u003Ctd>\n\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F81840-15-5_1193291.html#duXinDiv\">维司力农毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Cp> 以6-氨基-3，4-二氢-2(1H)-喹啉酮为原料。将6-氨基-3，4-二氢-2(1H)-喹啉酮(21.1g，0.13mo1)和双(伊溴乙基)胺氢溴酸盐(40.5g，0.13mo1)溶于150ml乙醇，回流搅拌8h。冷却，加入碳酸钠(13.8g，0.13mo1)，再回流搅拌8h。冷至室温，过滤收集析出的沉淀，用乙醇洗，乙醇-水重结晶，得26.4g无色针状结晶的3，4-二氢-6-(1-哌嗪基)-2(1H)-喹啉酮氢溴酸盐，收率64%，熔点289--293℃(分解)。\u003Cbr \u002F>将上述得到的喹啉酮衍生物(3.1g，0.010mo1)和三乙胺(2.2g，0.022mo1)溶于40ml无水二甲基甲酰胺，在冰浴冷却和搅拌下，滴加3，4-二甲氧苯甲酰氯(2.2g，0.0l 1mo1)在10ml无水二甲基甲酰胺中的溶液。加毕，在室温下搅拌1h。将反应液倾入冰水，用氯仿提取。提取液水洗，无水硫酸钠干燥，减压浓缩。剩余物用硅胶层析，氯仿-甲醇(100：1)洗脱。然后再用乙醇-氯仿重结晶，得2.7g无色颗粒状结晶的维司力农，收率70%，熔点238～239.5℃。 \u003C\u002Fp>","2026-08-21T07:51:12.859463Z",false,[290,296,301,307,313,319],{"slug":291,"cid":292,"name":293,"nameZh":294,"cas":295},"785882572553981952","J-1110759-4","Methyl Violet 2B","甲基紫2B","8004-87-3",{"slug":297,"cid":298,"name":299,"nameZh":299,"cas":300},"785911446427930624","J-69315-4","9-Bromo-10-(naphthalen-1-yl-d7)anthracene-1,2,3,4,5,6,7,8-d8","2330770-73-3",{"slug":302,"cid":303,"name":304,"nameZh":305,"cas":306},"785884696738271232","J-1324442-0","Ethylenediaminetetraacetate-copper-ammonia complex","EDTA-铜铵络合物","67989-88-2",{"slug":308,"cid":309,"name":310,"nameZh":311,"cas":312},"785872510607429632","J-1334045-0","calcium saccharin","糖精钙","6485-34-3",{"slug":314,"cid":315,"name":316,"nameZh":317,"cas":318},"785898743068102656","J-1365189-3","Esomeprazole calcium","埃索美拉唑钙","161796-85-6",{"slug":320,"cid":321,"name":322,"nameZh":323,"cas":324},"785884051318771712","J-1114131-2","Alizarin Complexone","茜素络合指示剂","3952-78-1",1792674266883,"zh-CN",[]]