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\u002F kg体重）通过每天一次口服洗胃施用。每周两次通过腹膜内注射施用吉西他滨（PBS中50mg \u002F kg体重）。每周监测小鼠体重。继续治疗直至小鼠出现嗜睡，腹胀或体重减轻的迹象，此时将其处死。通过检测单个LoxP位点的存在，在小鼠胰腺中确认成功的切除 - 重组事件。大鼠[3]该研究在80只雌性Wistar大鼠中进行，初始重量约为250g。通过耳标识别动物并如下分组。将40只大鼠分成5组，每组8只：4组通过气管内喷雾分别以2,4,6和8mg \u002F kg的剂量肺组织给予吉西他滨（LD2，LD4，LD6，LD8组）和一组接受0.9％盐水载体溶液（组LDv）的喷雾给药。将剩余的40只大鼠分成5组，每组8只：4组分别通过管饲法分别以2,4,6和8mg \u002F kg的剂量口服递送吉西他滨（OD2，OD4，OD6，OD8组），组通过管饲法接受相同体积的0.9％盐水（组ODv）。该协议包括以1周为间隔的九个会话。在两个疗程之间，将动物保持在标准实验室条件下，并在每个笼子中由四只动物的一组饲养，其中有垫料并且可以自由获得颗粒食物和自来水。将笼子放置在与抽吸系统连接的封闭腔室中。",{"key":269,"value":270},"参考文献","[1].\nWang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80.\n[2].\nYip-Schneider MT, et al. Dimethylaminoparthenolide and Gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 17;13:194.\n[3].\nGagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer;18(2):198-206\n[4].\nLou M, et al. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Jun 2;292(22):9136-9149.\n[5].\nWang Y, et al. Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-κB signal pathways. 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